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Now showing items 3378-3397 of 3506
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U.S. FDA Approved Drugs from 2015-June 2020: A Perspective
(American Chemical Society, 2021-02-22)In the present work, we report compilation and analysis of 245 drugs, including small and macromolecules approved by the U.S. FDA from 2015 until June 2020. Nearly 29% of the drugs were approved for the treatment of various ... -
Ubiquitous Learning
(2017) -
Ultimate Ruin Probability for Benktander Gibrat Risk Model
(Springer, 2022-04-13)In actuarial science and finance, the derivation of ultimate ruin probability for various loss distributions is of key interest. There are many methods available in literature for evaluating ultimate ruin probability for ... -
Ultra-narrow blue phosphorene nanoribbons for tunable optoelectronics
(Royal Society of Chemistry, 2017)We report optoelectronic properties of ultra-narrow blue phosphorene nanoribbons (BPNRs) within the state-of-the-art density functional theory framework. The positive but small value of formation energy (?0.1 eV per atom) ... -
Unanticipated Cleavage of 2-Nitrophenyl-Substituted N-Formyl Pyrazolines under Bechamp Conditions: Unveiling the Synthesis of 2-Aryl Quinolines and Their Mechanistic Exploration via DFT Studies
(American Chemical Society, 2018)We herein report for the first time an unusual decomposition of 2-nitrophenyl-substituted N-formyl pyrazolines under Bechamp reduction condition employed to yield 2-aryl quinolines exclusively instead of pyrazolo[1,5-c]q ... -
Unanticipated Cleavage of 2-Nitrophenyl-Substituted N-Formyl Pyrazolines under Bechamp Conditions: Unveiling the Synthesis of 2-Aryl Quinolines and Their Mechanistic Exploration via DFT Studies.
(ACS Publications, 2018)We herein report for the first time an unusual decomposition of 2-nitrophenyl-substituted N-formyl pyrazolines under Bechamp reduction condition employed to yield 2-aryl quinolines exclusively instead of pyrazolo[1,5-c]q ... -
Uncovering the hydro-meteorological drivers responsible for forest fires utilizing geospatial techniques
(Springer, 2023-05-29)Forest fires have become a growing concern worldwide, with climate change exacerbating their frequency and intensity. In the Simlipal region of India, forest fires are relatively rare; however, in 2021, significant damage ... -
Understanding cross-tolerance mechanism and effect of drought priming on individual heat stress and combinatorial heat and drought stress in chickpea
(Springer, 2022-03-15)In northern India, chickpea experiences abrupt heat and drought stress during the late developmental stage and entails significant production loss. In the present study, the effect of heat stress and combined stress (heat ... -
Understanding cross-tolerance mechanism and effect of drought priming on individual heat stress and combinatorial heat and drought stress in chickpea
(Springer, 2022-03-15)In northern India, chickpea experiences abrupt heat and drought stress during the late developmental stage and entails significant production loss. In the present study, the effect of heat stress and combined stress (heat ... -
Understanding human thiol dioxygenase enzymes: structure to function and biology to pathology
(Wiley, 2017)Amino acid metabolism is a significant metabolic activity in humans, especially of sulphur-containing amino acids, methionine and cysteine (Cys). Cys is cytotoxic and neurotoxic in nature; hence, mammalian cells maintain ... -
Understanding Immune-etiology of Psoriasis: An autoimmune disease
(Central University of Punjab, 2018)Psoriasis is a chronic inflammatory autoimmune disease. Disease etiology is understood in terms of altered crosstalk between skin keratinocytes and immune cell infiltrates, specifically T cells leading to the development ... -
Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis
(MDPI, 2023-03-28)Genetic variant(s) of concern (VoC) of SARS-CoV-2 have been emerging worldwide due to mutations in the gene encoding spike glycoprotein. We performed comprehensive analyses of spike protein mutations in the significant ... -
Understanding plant-plant growth-promoting rhizobacteria (PGPR) interactions for inducing plant defense
(Elsevier, 2023-04-21)Rhizobacteria fostering plant growth have received considerable attention in modern agriculture as they are capable of enhancing growth of the plants and are also a chemical fertilizer replacement. Besides enhancing growth, ... -
Understanding plant-plant growth-promoting rhizobacteria (PGPR) interactions for inducing plant defense
(Elsevier, 2023-04-21)Rhizobacteria fostering plant growth have received considerable attention in modern agriculture as they are capable of enhancing growth of the plants and are also a chemical fertilizer replacement. Besides enhancing growth, ... -
Understanding the Cross-Talk between the Ceramide Biosynthetic Pathway and Mitochondrial Function in Multiple Sclerosis and Demyelinating Disorders
(Wiley-Hindawi, 2023-10-12)Myelin is a spiral compilation of uniformly thick membranes around the axon in an alternating fashion, and it is formed by a complicated process known as myelination. Myelin sheaths are responsible for various physiological ... -
Understanding the impact of sociosexual interactions on sleep using Drosophila melanogaster as a model organism
(Frontiers Media SA, 2023-08-21)Sleep is conserved across species, and it is believed that a fixed amount of sleep is needed for normal neurobiological functions. Sleep rebound follows sleep deprivation; however, continuous sleep deprivation for longer ... -
Understanding the multifaceted role of ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) and its altered behaviour in human diseases
(Bentham Science Publishers B.V., 2015)Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) also known as Autotaxin, is a secreted lysophospholipase D, which hydrolyzes lysophosphatidylcholine (LPC) into Lysophosphatidic acid (LPA). LPA is the bioactive ... -
Understanding the multifaceted role of miRNAs in Alzheimer�s disease pathology
(Springer, 2023-07-28)Small non-coding RNAs (miRNAs) regulate gene expression by binding to mRNA and mediating its degradation or inhibiting translation. Since miRNAs can regulate the expression of several genes, they have multiple roles to ... -
Understanding the multifaceted role of miRNAs in Alzheimer�s disease pathology
(Springer, 2023-07-28)Small non-coding RNAs (miRNAs) regulate gene expression by binding to mRNA and mediating its degradation or inhibiting translation. Since miRNAs can regulate the expression of several genes, they have multiple roles to ... -
Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer's disease
(Elsevier B.V., 2023-09-13)Synaptic mitochondria are crucial for maintaining synaptic activity due to their high energy requirements, substantial calcium (Ca2+) fluctuation, and neurotransmitter release at the synapse. To provide a continuous energy ...