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Now showing items 1634-1653 of 3506
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In silico identification of potential ?-secretase inhibitor of marine-algal origin: an anticancer intervention
(Taylor and Francis Ltd., 2022-12-28)Gamma secretase (GS) activates notch signalling pathway (NSP) by liberating the truncated notch intracellular domain (NICD). The NSP is associated with the cancer development and progression, which makes GS a potential ... -
In silico molecular docking study of natural compounds on wild and mutated epidermal growth factor receptor
(Birkhauser Boston, 2014)The role played by overexpression of tyrosine kinase epidermal growth factor receptor (EGFR), the transmembrane receptor central to numerous cellular processes comprising cell migration, adhesion, apoptosis, and cell ... -
In silico molecular interaction studies of chitosan polymer with aromatase inhibitor: Leads to letrozole nanoparticles for the treatment of breast cancer
(Bentham Science Publishers, 2020-08-26)Background: It takes a lot more studies to evaluate the molecular interaction of nanoparticles with the drug, their drug delivery potential and release kinetics. Thus, we have taken in silico and in vitro approaches into ... -
In silico phytochemical repurposing of natural molecules as entry inhibitors against RBD of the spike protein of SARS-CoV-2 using molecular docking studies
(Inderscience Publishers, 2023-04-18)The receptor binding domain (RBD) of Spike-protein (S-protein) is responsible for virus entry via interaction with host protein ACE2 (angiotensin-converting enzyme 2), present on the cell surface of humans. Therefore, ... -
In silico screening and molecular interaction studies of tetrahydrocannabinol and its derivatives with acetylcholine binding protein
(Bentham Science Publishers B.V., 2018)Background: Alzheimer’s disease (AD) is the fourth largest cause of death among people over 65 years of age. Accumulation of β-amyloid and cholinergic deficiency are two prominent pathological descriptions for AD. Objective: ... -
In Silico Studies of Indole Derivatives as Antibacterial Agents
(Korean Pharmacopuncture Institute, 2023-06-30)Objectives: Molecular docking and QSAR studies of indole derivatives as antibacterial agents. Methods: In this study, we used a multiple linear regressions (MLR) approach to construct a 2D quantitative structure activity ... -
In silico Studies of Plant-Derived Bioactive Compounds of Wedelia Species
(Bentham Science Publishers, 2022-05-19)Background: In India, several types of plants have been researched for the treatment of various ailments. Wedelia species, belonging to the Asteraceae family, is one of the wonder plants that has been utilised in Unani, ... -
In silico study of flavonoids as DPP-4 and α-glucosidase inhibitors
(Bentham Science Publishers B.V., 2018)Background: Diabetes being among the most prevalent disease is being studied widely to achieve most potent drug with lesser side-effects. Numerous targets have been explored and several drugs have been developed to combat ... -
In Silico Study of the Structural Disruption of 14?-demethylase Induced by the Binding of Terminalia chebula Constituents
(Bentham Science Publishers, 2023-07-11)Background: Since ancient times, medicinal plants have been in use in medicine and daily life. Objective: To develop new antifungal compounds with low toxicity and high efficacy followed by high bioavailability, the ... -
In situ reductive regeneration of zerovalent iron nanoparticles immobilized on cellulose for atom efficient Cr( VI ) adsorption
(Royal Society of Chemistry, 2015)Zerovalent iron nanoparticles (nZVI) (11.8 ± 0.2% w/w) immobilized on microcrystalline cellulose (C-nZVI) were synthesized and studied for Cr(VI) sorption. The material showed good atom economy for Cr(VI) adsorption (562.8 ... -
In situ reductive regeneration of zerovalent iron nanoparticles immobilized on cellulose for atom efficient Cr(vi) adsorption
(Royal Society of Chemistry, 2015)Zerovalent iron nanoparticles (nZVI) (11.8 - 0.2% w/w) immobilized on microcrystalline cellulose (C-nZVI) were synthesized and studied for Cr(vi) sorption. The material showed good atom economy for Cr(vi) adsorption (562.8 ... -
In vitro and In silico study of Essential oil Components from Eucalyptus tereticornis as Antibacterial agents
(Central University of Punjab, 2018)Many essential oils are known for their antimicrobial activity and the main target is bacterial cell membrane which is important for bacterial viability and hence the study was done to find the target and effective binding ... -
An in vitro study ascertaining the role of H2O2 and glucose oxidase in modulation of antioxidant potential and cancer cell survival mechanisms in glioblastoma U-87 MG cells
(Springer New York LLC, 2017)Glial cells protect themselves from the elevated reactive oxygen species (ROS) via developing unusual mechanisms to maintain the genomic stability, and reprogramming of the cellular antioxidant system to cope with the ... -
In Vivo Anticancer Evaluation of 6b, a Non-Covalent Imidazo[1,2-a]quinoxaline-Based Epidermal Growth Factor Receptor Inhibitor against Human Xenograft Tumor in Nude Mice
(MDPI, 2022-08-30)Tyrosine kinase inhibitors are validated therapeutic agents against EGFR-mutated non-small cell lung cancer (NSCLC). However, the associated critical side effects of these agents are inevitable, demanding more specific and ... -
An in-silico approach on essential oil molecules as apoptosis inducer in cancer chemotherapy
(Innovations in Pharmaceuticals and Pharmacotherapy, 2017)Essential oils (EOs) are very engrossing natural plant products and apart from this they possess various biological properties. It has been reported that these essential oil molecules are able to inhibit tumor cell ... -
In-Vehicle Interaction Systems, Eye Movements, and Safety
(SAGE Publications Inc., 2022-10-10)In-vehicle interactive systems are widely used in modern vehicles. While these systems serve various purposes, they are also potential distracters for drivers. In this study we investigated the effect of in-vehicle spatial ... -
In-vitro anti-mutagenic activity of Asparagus racemosus: An ayurvedic medicinal plant
(Academic Journals Inc., 2013)Asparagus racemosus is a plant traditionaly used in epilepsy, as a brain tonic, cardiac disorders, hypertension, habitual abortions, weakness of the uterus, excessive bleeding during menstruation. The current study evaluated ... -
In-vitro guided fractionation of crude root extracts of potentilla atrosanguinea lodd and in-silico of polyphenolic compounds
(Central University of Punjab, 2013)Modern therapeutic system is a kind of inspiration from traditional plant based medicine used for various diseases and ailments. Advancement in drug discovery technology including computational drug design and bioassay ... -
Inactivation of bacterial pathogenic load in compost against vermicompost of organic solid waste aiming to achieve sanitation goals: A review
(Elsevier Ltd, 2017)Waste management strategies for organic residues, such as composting and vermicomposting, have been implemented in some developed and developing countries to solve the problem of organic solid waste (OSW). Yet, these ... -
The incidence of male breast cancer: from fiction to reality - correspondence
(NLM (Medline), 2023-05-24)[No abstract available]