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Now showing items 900-919 of 3506
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Drug-metabolizing enzymes: role in drug resistance in cancer
(Springer, 2020)Although continuous researches are going on for the discovery of new chemotherapeutic agents, resistance to these anticancer agents has made it really difficult to reach the fruitful results. There are many causes for this ... -
Dual aromatase-steroid sulfatase inhibitors (DASI's) for the treatment of breast cancer: a structure guided ligand based designing approach
(Taylor and Francis Ltd., 2022-12-13)Dual aromatase-steroid sulfatase inhibitors (DASIs) lead to significant deprivation of estrogen levels as compared to a single target inhibition and thereby exhibited an additive or synergistic effect in the treatment of ... -
Dual Aromatase-Sulphatase Inhibitors (DASIs) for the Treatment of Hormone Dependent Breast Cancer
(Bentham Science Publishers, 2021-01-19)Breast cancer is the most frequently diagnosed cancer in women and the second most common form of cancer, causing death after lung cancer, all across the globe at an alarming rate. The level of estrogens in breast cancer ... -
Dual inhibitors of epidermal growth factor receptor and topoisomerase IIa derived from a quinoline scaffold
(Royal Society of Chemistry, 2016)Based on the quinazoline bearing EGFR inhibitors, a series of thirty four compounds having a quinoline scaffold were synthesised and evaluated in vitro for EGFR kinase inhibitory activity. A structure-activity relationship ... -
A dual stimuli responsive natural polymer based superabsorbent hydrogel engineered through a novel cross-linker
(Royal Society of Chemistry, 2021-03-23)Natural protein-based polymers may serve as a potential source for developing advanced porous organic macromolecules, possessing exquisite control over the pores, which impart exceptional properties to these materials. ... -
Dual-Functional 3-Acetyl-2,5-dimethylthiophene Additive-Assisted Crystallization Control and Trap State Passivation for High-Performance Perovskite Solar Cells
(American Chemical Society, 2022-11-25)Defect-mediated charge recombination and successive degradation mainly lag the performance of perovskite solar cells (PSCs). Insufficiency or evaporation of organic cations leaves behind the undercoordinated Pb2+ions, which ... -
Dumbbell-Shaped Ternary Transition-Metal (Cu, Ni, Co) Phosphate Bundles: A Promising Catalyst for the Oxygen Evolution Reaction
(American Chemical Society, 2022-01-27)Development of economical and high-performance electrocatalysts for the oxygen evolution reaction (OER) is of tremendous interest for future applications as sustainable energy materials. Here, a unique member of efficient ... -
A duodenal mucosa transcriptome study identified reduced expression of a novel gene CDH18 in celiac disease
(Elsevier B.V., 2023-10-09)Background: Celiac disease (CD) a complex immune disease that affects duodenal mucosa. Identification of tissue specific biomarkers is expected to improve the existing biopsy based CD diagnosis. Aims: To investigate the ... -
DWT-SVD Based robust digital image watermarking using adaptive median filter
(Central University of Punjab, 2013)Feature Matching is one of the central issues of model-based recognition and an important component of most object recognition systems. The feature matching technique can be applied in image alignment, 3D secure reconstruction, ... -
Dynamic Axial Chirality in Drug Design and Discovery: Introduction to Atropisomerism, Classification, Significance, Recent Trends and Challenges
(Springer Singapore, 2021-02-18)Induction of chirality in non-chiral ligands via involvement of hindered rotation around a single bond has led to the development of atropisomers. The atropisomers behave similarly as the chiral compounds and impact the ... -
The Dynamic Effects of SAARC: a panel analysis
(Serials Publications, 2010) -
Dynamics of cholera disease by using two recent fractional numerical methods
(Mehmet Yavuz, 2021-12-22)In this paper, we simulate an epidemic model of cholera disease in the sense of generalized Liouville-Caputo fractional derivative. We provide the results related to the existence of a unique solution by using some well-known ... -
DYNAMICS OF STRUCTURAL CHANGES IN INDIA’S EXPORTS, 1980-2016
(Central University of Punjab, 2018)The international trade flows have been dramatically expanding due to the growing integration of the world economies and have experienced spectacular changes over the past few decades. For that reason, the present study ... -
Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
(MDPI, 2022-08-18)Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase dynamin acts as a �molecular scissor� to form ... -
Dysregulated autophagy: A key player in the pathophysiology of type 2 diabetes and its complications
(Elsevier B.V., 2023-02-14)Autophagy is essential in regulating the turnover of macromolecules via removing damaged organelles, misfolded proteins in various tissues, including liver, skeletal muscles, and adipose tissue to maintain the cellular ... -
Dysregulated miRNAs in Progression and Pathogenesis of Alzheimer�s Disease
(Springer, 2022-07-22)Alzheimer�s disease (AD) is a progressive degeneration of neurons due to the accumulation of amyloid-? peptide (A?) and hyper-phosphorylation of tau protein in the neuronal milieu leading to increased oxidative stress and ... -
E-pharmacophore guided discovery of pyrazolo[1,5-c]quinazolines as dual inhibitors of topoisomerase-I and histone deacetylase
(Academic Press Inc., 2020)In the quest to ameliorate the camptothecin (CPT) downsides, we expedite to search for stable non-CPT analogues among 11 motifs of pyrazoloquinazolines reported. E-pharmacophore drug design approach helped filtering out ... -
E-selectin gene (S128R) polymorphism in hemorrhagic stroke: Comparison with ischemic stroke
(Elsevier Ireland Ltd, 2014)Increasing evidence suggests that genetic variation in inflammatory genes plays a pivotal role in pathogenesis of stroke. The aim of the present study was to evaluate the association of E-selectin S128R polymorphism with ... -
E-waste Management Practices in India: Challenges and Approaches
(Springer International Publishing, 2023-03-01)In the current era of rising consumerism and information technology, e-waste has emerged as a serious problem besides plastic pollution. The rising concern for e-waste has both economic, environmental and health consequences. ... -
Ecocentric vision in the works of J.M. Coetzee and AND Amitav Ghosh: A comparative study of life and times of MICHAEL K AND THE GLASS PALACE
(Central University of Punjab, 2014)Environmental destruction has been a burning issue from the last few decades. The ego-centric attitude and rational thinking of man has led to the imbalance of the entire environment and its surroundings. The novels selected ...