Browsing by Author "Jain, Aklank"
Now showing items 1-20 of 41
-
Advancing Cancer Immunotherapy: The Potential of mRNA Vaccines As a Promising Therapeutic Approach
Goyal, Falak; Chattopadhyay, Anandini; Navik, Umashanker; Jain, Aklank; Reddy, P. Hemachandra; Bhatti, Gurjit Kaur; Bhatti, Jasvinder Singh (John Wiley and Sons Inc, 2023-10-04)mRNA vaccines have long been recognized for their ability to induce robust immune responses. The discovery that mRNA vaccines may also contribute to antitumor immunity has made them a promising therapeutic approach against ... -
Ampelopsin targets in cellular processes of cancer: Recent trends and advances
Tuli, Hardeep Singh; Sak, Katrin; Garg, Vivek Kumar; Kumar, Ajay; Adhikary, Shubham; Kaur, Ginpreet; Parashar, Nidarshana Chaturvedi; Parashar, Gaurav; Mukherjee, Tapan Kumar; Sharma, Uttam; Jain, Aklank; Mohapatra, Ranjan K.; Dhama, Kuldeep; Kumar, Manoj; Singh, Tejveer (Elsevier Inc., 2022-07-27)Cancer is being considered as a serious threat to human health globally due to limited availability and efficacy of therapeutics. In addition, existing chemotherapeutic drugs possess a diverse range of toxic side effects. ... -
Application of curcumin nanoformulations to target folic acid receptor in cancer: Recent trends and advances
Hussain, Arif; Kumar, Ajay; Uttam, Vivek; Sharma, Uttam; Sak, Katrin; Saini, Reena V.; Saini, Adesh K.; Haque, Shafiul; Tuli, Hardeep Singh; Jain, Aklank; Sethi, Gautam (Academic Press Inc., 2023-06-20)Curcumin, derived from turmeric, has a strong anticancer potential known for millennia. The development of this phytochemical as a medicine has been hampered by several significant deficiencies, including its poor water ... -
Atypical leishmaniasis: A global perspective with emphasis on the Indian subcontinent
Thakur L.; Singh K.K.; Shanker V.; Negi A.; Jain, Aklank; Matlashewski G.; Jain, Manju (Public Library of Science, 2018)Background: Among the neglected tropical diseases, leishmaniasis continues to be prevalent in many tropical and subtropical countries despite international, national, and local efforts towards its control and elimination ... -
Biosynthesis of Zinc Oxide Nanoparticles Using Catharanthus Roseus Leaves and Their Therapeutic Response in Breast Cancer (MDA-MB-231) Cells
Bangroo, Apoorva; Malhotra, Akshay; Sharma, Uttam; Jain, Aklank; Kaur, Anupreet (Routledge, 2021-07-26)As the current study reports the utilization of the leaf extract of Catharanthus roseus (C.roseus) for the biological synthesis of zinc oxide nanoparticles (ZnO NPs) because of the importance of the importance of health ... -
Circulating long non-coding RNA EWSAT1 acts as a liquid biopsy marker for esophageal squamous cell carcinoma: A pilot study
Uttam, Vivek; Rana, Manjit Kaur; Sharma, Uttam; Singh, Karuna; Jain, Aklank (KeAi Communications Co., 2023-10-28)The widespread public health problem of esophageal squamous cell carcinoma (ESCC) is the cause of an increasing number of deaths each year due to delayed diagnosis. Therefore, we require specific and sensitive new biomarkers ... -
Circulating Long Non-Coding RNAs LINC00324 and LOC100507053 as Potential Liquid Biopsy Markers for Esophageal Squamous Cell Carcinoma: A Pilot Study
Sharma, Uttam; Barwal, Tushar Singh; Khandelwal, Akanksha; Rana, Manjit Kaur; Rana, Amrit Pal Singh; Singh, Karuna; Jain, Aklank (Frontiers Media S.A., 2022-02-14)Background: Despite the availability of advanced technology to detect and treat esophageal squamous cell carcinoma (ESCC), the 5-year survival rate of ESCC patients is still meager. Recently, long non-coding RNAs (lncRNAs) ... -
Circulating miR-320a Acts as a Tumor Suppressor and Prognostic Factor in Non-small Cell Lung Cancer
Khandelwal, Akanksha; Sharma, Uttam; Barwal, Tushar Singh; Seam, Rajeev Kumar; Gupta, Manish; Rana, Manjit Kaur; Vasquez, Karen M.; Jain, Aklank (Frontiers Media S.A., 2021-03-23)Dysregulated expression profiles of microRNAs (miRNAs) have been observed in several types of cancer, including non-small cell lung cancer (NSCLC); however, the diagnostic and prognostic potential of circulating miRNAs in ... -
Clinical potential of long non-coding RNA LINC01133 as a promising biomarker and therapeutic target in cancers
Sharma, Uttam; Barwal, Tushar Singh; Murmu, Masang; Acharya, Varnali; Pant, Neha; Dey, Damayanti; Vivek; Gautam, Ashima; Bazala, Sonali; Singh, Ipsa; Azzouz, Farah; Bishayee, Anupam; Jain, Aklank (Newlands Press Ltd, 2022-02-23)Recently, long intergenic non-protein coding RNA 01133 (LINC01133) was identified as a novel transcript in cancers. It modulates various hallmarks of cancers and acts as oncogenic in some cancers while tumor-suppressive ... -
A diagnostic and prognostic value of blood-based circulating long non-coding RNAs in thyroid, pancreatic and ovarian cancer
Barwal, Tushar Singh; Sharma, Uttam; Rana, Manjit Kaur; Bazala, Sonali; Singh, Ipsa; Murmu, Masang; Kapoor, Harmanpreet Singh; Thakur, Smriti; Jain, Manju; Jain, Aklank (Elsevier Ireland Ltd, 2022-01-13)Several studies have demonstrated the potential of circulating long non-coding RNAs (lncRNAs) as promising cancer biomarkers. Herein, we addressed the regulatory role of circulating lncRNAs and their potential value as ... -
The emerging role of long non-coding RNA in gallbladder cancer pathogenesis
Khandelwal, Akanksha; Malhotra, Akshay; Jain, Manju; Vasquez, Karen M.; Jain, Aklank; Khandelwal, A.; Malhotra, A.; Jain, M.; Vasquez, K.M.; Jain, A. (Elsevier B.V., 2017)Gallbladder cancer (GBC) is the most common and aggressive form of biliary tract carcinoma with an alarmingly low 5-year survival rate. Despite its high mortality rate, the underlying mechanisms of GBC pathogenesis are not ... -
Evolution of Frozen Section in Carcinoma Breast: Systematic Review
Rana, Manjit Kaur; Rana, Amrit Pal Singh; Sharma, Uttam; Barwal, Tushar Singh; Jain, Aklank (Hindawi Limited, 2022-05-23)Background. The frozen section (FS) has been a good technique in surgical management of breast lesions since many years. But complete agreement and cooperation have not been achieved everywhere among surgeons and pathologists ... -
Expression analysis of long non-coding RNA GAS5 and BANCR in lung cancer cell line A549 compared to IMR-90.
Sharma, Uttam (Central University of Punjab, 2018)Lung cancer is the major cause of death worldwide. Several chemotherapeutic drugs and therapies have been established, but the early diagnosis and prognosis of lung cancer is still a question. Long non-coding RNAs are ... -
Expression Study of Long non-coding RNA SCAL1 and GAS6-AS1 in Lung cancer Cell line A549 Compared to IMR-90
Pp, Arifa (Central University of Punjab, 2018)Lung cancer is the fatal type of cancer owing to maximum number death worldwide. Despite the advances in clinical and experimental setup lung cancer still is the deadliest type of cancer wherein survival rate is as low as ... -
Galangin: A metabolite that suppresses anti-neoplastic activities through modulation of oncogenic targets
Tuli, Hardeep Singh; Sak, Katrin; Adhikary, Shubham; Kaur, Ginpreet; Aggarwal, Diwakar; Kaur, Jagjit; Kumar, Manoj; Parashar, Nidarshana Chaturvedi; Parashar, Gaurav; Sharma, Uttam; Jain, Aklank (SAGE Publications Inc., 2021-12-14)With the dramatic increase in cancer incidence all over the world in the last decades, studies on identifying novel efficient anti-cancer agents have been intensified. Historically, natural products have represented one ... -
Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease
Prakash, Hridayesh; Upadhyay, Dilip; Bandapalli, Obul Reddy; Jain, Aklank; Kleuser, Burkhard (Elsevier Inc., 2020-11-02)Sphingolipids are potent bioactive agents involved in the pathogenesis of various respiratory bacterial infections. To date, several sphingolipid derivatives are known, but S1P (Sphingosine-1-phosphate) and Ceramide are ... -
The imminent role of microRNAs in salivary adenoid cystic carcinoma
Kumar, Pawan; Kumawat, Ram Kumar; Uttam, Vivek; Behera, Alisha; Rani, Medha; Singh, Neha; Barwal, Tushar Singh; Sharma, Uttam; Jain, Aklank (Neoplasia Press, Inc., 2022-11-04)Unfortunately, despite the severe problem associated with salivary adenoid cystic carcinoma (SACC), it has not been studied in detail yet. Therefore, the time has come to understand the oncogenic cause of SACC and find the ... -
Impact of noncoding RNAs on cancer directed immune therapies: Now then and forever
Roy, Roshan Kumar; Yadav, Rakhi; Sharma, Uttam; Wasson, Mishi Kaushal; Sharma, Ashok; Tanwar, Pranay; Jain, Aklank; Prakash, Hridayesh (John Wiley and Sons Inc, 2022-04-30)Accumulating evidence demonstrates that the host genome's epigenetic modifications are essential for living organisms to adapt to extreme conditions. DNA methylation, covalent modifications of histone and interassociation ... -
An Insight Into Systemic Immune Response in Leishmania donovani Mediated Atypical Cutaneous Leishmaniasis in the New Endemic State of Himachal Pradesh, India
Thakur, Lovlesh; Madaan, Priyanka; Jain, Aklank; Shankar, Vinay; Negi, Ajeet; Chauhan, Shashi Bhushan; Sundar, Shyam; Singh, Om Prakash; Jain, Manju (Frontiers Media S.A., 2022-01-04)Leishmaniasis continues to afflict known and newer endemic sites despite global efforts towards its control and elimination. In this regard, the emergence of newer endemic sites with unusual disease formats is recognized ... -
An intraspecies Leishmania donovani hybrid from the Indian subcontinent is associated with an atypical phenotype of cutaneous disease
Lypaczewski, Patrick; Thakur, Lovlesh; Jain, Aklank; Kumari, Sandhya; Paulini, Kayla; Matlashewski, Greg; Jain, Manju (Elsevier Inc., 2022-01-22)Leishmaniasis is a neglected tropical disease endemic in over 90 countries. The disease has two main pathologies; cutaneous leishmaniasis (CL) that generally self-heals, and visceral leishmaniasis (VL) that is fatal if ...