Browsing by Author "Jain, Manju"
Now showing items 1-16 of 16
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Atypical leishmaniasis: A global perspective with emphasis on the Indian subcontinent
Thakur L.; Singh K.K.; Shanker V.; Negi A.; Jain, Aklank; Matlashewski G.; Jain, Manju (Public Library of Science, 2018)Background: Among the neglected tropical diseases, leishmaniasis continues to be prevalent in many tropical and subtropical countries despite international, national, and local efforts towards its control and elimination ... -
A diagnostic and prognostic value of blood-based circulating long non-coding RNAs in thyroid, pancreatic and ovarian cancer
Barwal, Tushar Singh; Sharma, Uttam; Rana, Manjit Kaur; Bazala, Sonali; Singh, Ipsa; Murmu, Masang; Kapoor, Harmanpreet Singh; Thakur, Smriti; Jain, Manju; Jain, Aklank (Elsevier Ireland Ltd, 2022-01-13)Several studies have demonstrated the potential of circulating long non-coding RNAs (lncRNAs) as promising cancer biomarkers. Herein, we addressed the regulatory role of circulating lncRNAs and their potential value as ... -
The emerging role of long non-coding RNA in gallbladder cancer pathogenesis
Khandelwal, Akanksha; Malhotra, Akshay; Jain, Manju; Vasquez, Karen M.; Jain, Aklank; Khandelwal, A.; Malhotra, A.; Jain, M.; Vasquez, K.M.; Jain, A. (Elsevier B.V., 2017)Gallbladder cancer (GBC) is the most common and aggressive form of biliary tract carcinoma with an alarmingly low 5-year survival rate. Despite its high mortality rate, the underlying mechanisms of GBC pathogenesis are not ... -
An Insight into Immunopathology of Leishmaniasis
Chauhan, Yogesh; Nikita, Rajkumari; Madaan, Priyanka; Jain, Manju (Springer Nature, 2023-01-31)Leishmaniasis is a disease complex with clinical manifestations ranging from systemic visceral leishmaniasis (VL) to cutaneous leishmaniasis (CL) with skinrestricted lesions to mucocutaneous leishmaniasis (MCL) that extends ... -
An Insight Into Systemic Immune Response in Leishmania donovani Mediated Atypical Cutaneous Leishmaniasis in the New Endemic State of Himachal Pradesh, India
Thakur, Lovlesh; Madaan, Priyanka; Jain, Aklank; Shankar, Vinay; Negi, Ajeet; Chauhan, Shashi Bhushan; Sundar, Shyam; Singh, Om Prakash; Jain, Manju (Frontiers Media S.A., 2022-01-04)Leishmaniasis continues to afflict known and newer endemic sites despite global efforts towards its control and elimination. In this regard, the emergence of newer endemic sites with unusual disease formats is recognized ... -
An intraspecies Leishmania donovani hybrid from the Indian subcontinent is associated with an atypical phenotype of cutaneous disease
Lypaczewski, Patrick; Thakur, Lovlesh; Jain, Aklank; Kumari, Sandhya; Paulini, Kayla; Matlashewski, Greg; Jain, Manju (Elsevier Inc., 2022-01-22)Leishmaniasis is a neglected tropical disease endemic in over 90 countries. The disease has two main pathologies; cutaneous leishmaniasis (CL) that generally self-heals, and visceral leishmaniasis (VL) that is fatal if ... -
Leishmania donovani persistence and circulation causing cutaneous leishmaniasis in unusual-foci of Nepal
Rai, Tinmaya; Shrestha, Srijan; Prajapati, Sabita; Bastola, Anup; Parajuli, Niraj; Ghimire, Pragya Gautam; Bhandari, Parmananda; Pandey, Kishor; Jain, Manju; Matlashewski, Greg; Bras-Goncalves, Rachel; Manandhar, Krishna Das (Nature Research, 2023-07-29)Cutaneous leishmaniasis cases have increased dramatically in recent years in Nepal. The study offers molecular identification of the Leishmania species using 40 patient�s aspiration biopsy samples, targeting markers ... -
Micrornas and long noncoding rnas as novel therapeutic targets in estrogen receptor-positive breast and ovarian cancers
Barwal, Tushar Singh; Sharma, Uttam; Bazala, Sonali; Singh, Ipsa; Jain, Manju; Prakash, Hridayesh; Shekhar, Shashank; Sandberg, Elise N.; Bishayee, Anupam; Jain, Aklank (MDPI, 2021-04-15)Aromatase inhibitors (AIs) such as anastrozole, letrozole, and exemestane have shown to prevent metastasis and angiogenesis in estrogen receptor (ER)-positive breast and ovarian tumors. They function primarily by reducing ... -
miR-590�5p: A double-edged sword in the oncogenesis process
Barwal, Tushar Singh; Singh, Neha; Sharma, Uttam; Bazala, Sonali; Rani, Medha; Behera, Alisha; Kumawat, Ram Kumar; Kumar, Pawan; Uttam, Vivek; Khandelwal, Akanksha; Barwal, Jyoti; Jain, Manju; Jain, Aklank (Elsevier Ltd, 2022-06-12)Accumulating evidence suggests the critical role of miR-590�5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590�5p acts as an oncogene in ... -
A panel of blood-based circulatory miRNAs with diagnostic potential in patients with psoriasis
Madaan, Priyanka; Sharma, Uttam; Tyagi, Nipanshi; Brar, Balvinder Kaur; Bansal, Shivani; Kushwaha, Hemant Rituraj; Kapoor, Harmanpreet Singh; Jain, Aklank; Jain, Manju (Frontiers Media SA, 2023-08-28)Psoriasis is a chronic inflammatory skin disease with keratinocyte hyperproliferation and T cells as key mediators of lesional and systemic inflammatory changes. To date, no suitable differential biomarkers are available ... -
A Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/?-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response
Sharma, Uttam; Murmu, Masang; Barwal, Tushar Singh; Tuli, Hardeep Singh; Jain, Manju; Prakash, Hridayesh; Kaceli, Tea; Jain, Aklank; Bishayee, Anupam (MDPI, 2022-03-28)Despite the availability of modern techniques for the treatment of esophageal squamous cell carcinoma (ESCC), tumor recurrence and metastasis are significant challenges in clinical management. Thus, ESCC possesses a poor ... -
The regulatory roles of long non-coding RNAs in the development of chemoresistance in breast cancer
Malhotra, Akshay; Jain, Manju; Prakash, Hridayesh; Vasquez, Karen M.; Jain, Aklank; Malhotra, A.; Jain, M.; Prakash, H.; Vasquez, K.M.; Jain, A. (Impact Journals LLC, 2017)Chemoresistance is one of the major hurdles in the treatment of breast cancer, which limits the effect of both targeted and conventional therapies in clinical settings. Therefore, understanding the mechanisms underpinning ... -
Role of sphingosine-1-phosphate in mast cell functions and asthma and its regulation by non-coding RNA
Saluja, Rohit; Kumar, Ashok; Jain, Manju; Goel, Sudhir K.; Jain, Aklank (Frontiers Media S.A., 2017)Sphingolipid metabolites are emerging as important signaling molecules in allergic diseases specifically asthma. One of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), is involved in cell differentiation, ... -
STAT signaling as a target for intervention: from cancer inflammation and angiogenesis to non-coding RNAs modulation
Tuli, Hardeep Singh; Sak, Katrin; Iqubal, Ashif; Garg, Vivek Kumar; Varol, Mehmet; Sharma, Uttam; Chauhan, Abhishek; Yerer, Mukerrem Betul; Dhama, Kuldeep; Jain, Manju; Jain, Aklank (Springer Science and Business Media B.V., 2022-04-26)As a landmark, scientific investigation in cytokine signaling and interferon-related anti-viral activity, signal transducer and activator of transcription (STAT) family of proteins was first discovered in the 1990s. Today, ... -
Understanding Immune-etiology of Psoriasis: An autoimmune disease
Kumari, Anjna (Central University of Punjab, 2018)Psoriasis is a chronic inflammatory autoimmune disease. Disease etiology is understood in terms of altered crosstalk between skin keratinocytes and immune cell infiltrates, specifically T cells leading to the development ... -
Yin and yang of immunological memory in controlling infections: Overriding self defence mechanisms
Roy, Roshan Kumar; Yadav, Rakhi; Jain, Aklank; Tripathi, Vishwas; Jain, Manju; Singh, Sandhya; Prakash, Hridayesh (Taylor and Francis Ltd., 2021-04-19)Immunological memory is critical for host immunity and decisive for individual to respond exponentially to previously encountered infection. Both T and B cell memory are known to orchestrate immunological memory with their ...