Browsing by Author "Kalra, S"
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Anticancer activity of dihydropyrazolo [1, 5‐c] quinazolines against rat C6 glioma cells via inhibition of topoisomerase II
Kaur, G; Cholia, Raman Preet; Joshi, G; Amrutkar, S.M; Kalra, S; Mantha, Anil K.; Banerjee, U.C; Kumar, R. (wiley, 2018)The design and synthesis of dihydropyrazolo[1,5‐c]quinazolines (1a–h) as human topoisomerase II (TopoII) catalytic inhibitors are reported. The compounds were investigated for their antiproliferative activity against the ... -
Anticancer activity of dihydropyrazolo[1,5-c]quinazolines against rat C6 glioma cells via inhibition of topoisomerase II.
Kaur, G; Cholia, RP; Joshi, G; Amrutkar, SM; Kalra, S; Mantha, Anil K.; Banerjee, UC; Kumar, R. (Wiley, 2018)The design and synthesis of dihydropyrazolo[1,5‐c]quinazolines (1a–h) as human topoisomerase II (TopoII) catalytic inhibitors are reported. The compounds were investigated for their antiproliferative activity against the ... -
Exploration of Pd-catalysed four-component tandem reaction for one-pot assembly of pyrazolo[1,5-c]quinazolines as potential EGFR inhibitors
Ansari, A.J; Joshi, G; Yadav, U.P; Maurya, A.K; Agnihotri, V.K; Kalra, S; Kumar, R; Singh, S; Sawant, D.M. (Academic Press Inc., 2019)A series of pyrazolo[1,5-c]quinazolines as EGFR inhibitors was designed and synthesized by highly efficient and novel multicomponent route involving Pd-catalyzed tandem one-pot four-component reaction. The reaction proceeds ... -
Knoevenagel/tandem knoevenagel and michael adducts of cyclohexane-1,3-dione and aryl aldehydes: Synthesis, DFT studies, xanthine oxidase inhibitory potential, and molecular modeling
Arora, S; Joshi, G; Kalra, S; Wani, A.A; Bharatam, P.V; Kumar, Pradeep; Kumar, Raj (American Chemical Society, 2019)Xanthine oxidase (XO) plays a crucial role in the formation of uric acid by oxidative hydroxylation of purines. Herein, we report the design and synthesis of Knoevenagel/tandem Knoevenagel and Michael adducts of ... -
Novel 2-(substituted phenyl Imino)-5-benzylidene-4-thiazolidinones as possible non-ulcerogenic tri-action drug candidates: synthesis, characterization, biological evaluation And docking studies.
Chawla, P.; Kalra, S; Kumar, R; Ranjit, S; Saraf, S. (Springer, 2019)The present research was aimed at the synthesis and screening of 35 novel 2-(substituted phenyl imino)-5-benzylidene-4-thiazolidinones having different substitutions at imino phenyl and arylidene groups. The title compounds ... -
Relay tricyclic Pd (ii)/Ag (i) catalysis: design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR.
Sawant, D.M.; Sharma, S; Pathare, R.S; Joshi, G; Kalra, S; Sukanya, S; Maurya, A.K.; Metre, R.K; Agnihotri, V.K.; Khan, S.; Kumar, Raj; Pardasania, R. T. (Royal Society of Chemistry, 2018)Synthesis of pyrazolo[1,5-c]quinazolines from four easily available precursors is presented through a one-pot tricyclic Pd(II)/Ag(I) relay catalysis. The bimetallic relay cascade forges five new chemical bonds by concatenating ... -
A review on quinoline derived scaffolds as Anti-HIV Agents.
Chokkar, N.; Kalra, S; Chauhan, M; Kumar, Raj (Bentham Science, 2018)After restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV), infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS). This demands the vigorous need of suitable ... -
Synthetic versus Enzymatic Pictet-Spengler Reaction: An Overview.
Sharma, S; Kalra, S; Joshi, G; Singh, S; Kumar, R. (Bentham, 2018)Pictet-Spengler reactions is an irreplaceable part of cyclization reaction leading to the formation of indispensable heterocyclic moieties including imidazole, benzoxazole, pyrrole, indole and others having immense biological ...