Browsing by Author "Kalra, Sourav"
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Association of CYP2C19*2 and ALDH1A1*1/*2 variants with disease outcome in breast cancer patients: results of a global screening array
Kalra, Sourav; Kaur, Raman Preet; Ludhiadch, Abhilash; Shafi, Gowhar; Vashista, Rajesh; Kumar, Raj; Munshi, Anjana (Springer Verlag, 2018)Purpose: Cyclophosphamide and doxorubicin (adjuvant chemotherapy) are commonly used to treat breast cancer patients. Variation in the genes involved in pharmacodynamics and pharmacokinetics of these drugs plays an important ... -
Association of CYP2C19*2 and ALDH1A1*1/*2 variants with disease outcome in breast cancer patients: results of a global screening array.
Kalra, Sourav; Ludhiadch Abhilash; Shafi, Gowhar; Vashista, Rajesh; Kumar, Raj; Munshi, Anjana (Springer, 2018)Cyclophosphamide and doxorubicin (adjuvant chemotherapy) are commonly used to treat breast cancer patients. Variation in the genes involved in pharmacodynamics and pharmacokinetics of these drugs plays an important role ... -
Computational investigation of binding mechanism of substituted pyrazinones targeting corticotropin releasing factor-1 receptor deliberated for anti-depressant drug design
Shekhar, M.S; Venkatachalam, T; Sharma, C.S; Pratap, Singh, H; Kalra, Sourav; Kumar, N. (Taylor and Francis, 2019)In spite of various research investigations towards anti-depressant drug discovery program, no one drug has not yet launched last 20 years. Corticotropin-releasing factor-1 (CRF-1) is one of the most validated targets for ... -
Design, synthesis, biological evaluation of 3,5-diaryl-4,5-dihydro-1H-pyrazole carbaldehydes as non-purine xanthine oxidase inhibitors: Tracing the anticancer mechanism via xanthine oxidase inhibition
Joshi, Gaurav; Sharma, Manisha; Kalra, Sourav; Gavande, Navnath S.; Singh, Sandeep; Kumar, Raj (Academic Press Inc., 2021-01-07)Xanthine oxidase (XO) has been primarily targeted for the development of anti-hyperuriciemic /anti-gout agents as it catalyzes the conversion of xanthine and hypoxanthine into uric acid. XO overexpression in various cancer ... -
Flavonoids as P-glycoprotein inhibitors for multidrug resistance in cancer: an in-silico approach
Kumar, Amit; Kalra, Sourav; Jangid, Kailash; Jaitak, Vikas (Taylor and Francis Ltd., 2022-09-19)Cancer has become a leading cause of mortality due to non-communicable diseases after cardiovascular disease worldwide and is increasing day by day at a daunting pace. According to an estimate by 2040 there will be 28.4 ... -
Is highly expressed ACE 2 in pregnant women �a curse� in times of COVID-19 pandemic?
Dhaundiyal, Ankit; Kumari, Puja; Jawalekar, Snehal Sainath; Chauhan, Gaurav; Kalra, Sourav; Navik, Umashanker (Elsevier Inc., 2020-10-28)Angiotensin-converting enzyme 2 (ACE 2) is a membrane-bound enzyme that cleaves angiotensin II (Ang II) into angiotensin (1�7). It also serves as an important binding site for SARS-CoV-2, thereby, facilitating viral entry ... -
Molecular Docking and In Vitro Anticancer Screening of Synthesized Arylthiazole linked 2H-indol-2-one Derivatives as VEGFR-2 Kinase Inhibitors
Shalmali, Nishtha; Bawa, Sandhya; Ali, Md Rahmat; Kalra, Sourav; Kumar, Raj; Zeya, Bushra; Rizvi, Moshahid Alam; Partap, Sangh; Husain, Asif (Bentham Science Publishers, 2021-11-18)Background: Indoline-2,3-dione comprises a leading course group of heterocycles endowed with appealing biological actions, including anticancer activity. There are significant justifications for exploring the anticancer ... -
Pharmacogenetics of Cyclophosphamide and Doxorubicin in Breast Cancer & Synthesis and Biological Evaluation of New Imidazole Based Putative Anticancer Agents
Kalra, Sourav (Central University of Punjab, 2019)Breast cancer is the second most prevalent cancer in women worldwide. It is treated by various strategies, including surgery, radiation therapy, hormonal therapy, targeted therapy and chemotherapy. Chemotherapeutic drugs ... -
Pyrimidine containing epidermal growth factor receptor kinase inhibitors: Synthesis and biological evaluation
Joshi, Gaurav; Nayyar, Himanshu; Kalra, Sourav; Sharma, Praveen; Munshi, Anjana; Singh, Sandeep; Kumar, Raj (Blackwell Publishing Ltd, 2017)Structure-based design and synthesis of pyrimidine containing reversible epidermal growth factor receptor (EGFR) inhibitors 1a?d are reported. The compounds (1a?d) inhibited the EGFR kinase activity in vitro with IC50 range ... -
Rationalization of the activity Profile of Pyruvate Kinase Isozyme M2 (PKM2) Inhibitors using 3D QSAR
Kusuma, Merugumala; Arora, Sahil; Kalra, Sourav; Chaturvedi, Anuhar; Heuser, Michael; Kumar, Raj (Bentham Science Publishers, 2021-08-05)Introduction: Pyruvate kinase isozyme M2 (PKM2) was observed to be overexpressed and play a key role in cell growth and cancer cells' metabolism. During the past years, phytochemicals have been developed as new treatment ... -
Role of genomic alterations in HER2 positive breast carcinoma: Focus on susceptibility and trastuzumab-therapy
Singla, Heena; Kalra, Sourav; Kheterpal, Preeti; Kumar, Vinod; Munshi, Anjana (Bentham Science Publishers B.V., 2017)Background: Breast cancer is the most frequently diagnosed life-threatening malignancy among women, across the globe. HER2 positive is a distinct breast cancer subtype, on account of its unique biology and physiological ... -
Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors
Kalra, Sourav; Joshi, Gaurav; Munshi, Anjana; Kumar, Raj (Elsevier Masson SAS, 2017)There are around 20 Cyclin-dependent kinases (CDKs) known till date, and various research groups have reported their role in different types of cancer. The X-ray structures of some CDKs especially CDK2 was exploited in the ... -
Synthetic versus enzymatic pictet-spengler reaction: An overview
Sharma, Sachin; Joshi, Gaurav; Kalra, Sourav; Singh, Sandeep; Kumar, Raj (Bentham Science Publishers B.V., 2018)Background: Pictet-Spengler reactions is an irreplaceable part of cyclization reaction leading to the formation of indispensable heterocyclic moieties including imidazole, benzoxazole, pyrrole, indole and others having ... -
Toward an Understanding of Structural Insights of Xanthine and Aldehyde Oxidases: An Overview of their Inhibitors and Role in Various Diseases
Kumar, Raj; Joshi, Gaurav; Kler, Harveen; Kalra, Sourav; Kaur, Manpreet; Arya, Ramandeep (John Wiley and Sons Inc., 2018)Almost all drug molecules become the substrates for oxidoreductase enzymes, get metabolized into more hydrophilic products and eliminated from the body. These metabolites sometime may be more potent, active, inactive, or ...