Browsing by Author "Upadhyay, Shishir"
Now showing items 1-7 of 7
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Design, synthesis and biological evaluation of novel indole-xanthendione hybrids as selective estrogen receptor modulators
Singla, Ramit; Gupt,a Kunj Bihari; Upadhyay, Shishir; Dhiman Monisha; Jaitak Vikas (Elsevier Ltd, 2018)Ground breaking clinical therapeutic advances in the treatment of breast cancer (BC) is the introduction of selective estrogen receptor modulators (SERMs). We have expeditiously designed and synthesized indole-xanthendione ... -
Identification of novel indole based heterocycles as selective estrogen receptor modulator
Singla, Ramit; Prakash, Kunal; Bihari Gupta, Kunj; Upadhyay, Shishir; Dhiman, Monisha; Jaitak, Vikas (Academic Press Inc., 2018)In the present study, we have designed and synthesized indole derivatives by coalescing the indole nucleus with chromene carbonitrile and dihydropyridine nucleus. Two compounds 5c and 6d were selected from series I and II ... -
Identification of novel indole based heterocycles as selective estrogen receptor modulator.
Singla, Ramit; Prakash, Kunal; Gupta Kunj Bihari; Upadhyay, Shishir; Dhiman, Monisha; Jaitak, Vikas (Elsevier, 2018)In the present study, we have designed and synthesized indole derivatives by coalescing the indole nucleus with chromene carbonitrile and dihydropyridine nucleus. Two compounds 5c and 6d were selected from series I and II ... -
Methods to Detect Nitric Oxide and Reactive Nitrogen Species in Biological Sample
Kaur, Sharanjot; Gupta, Kunj Bihari; Kumar, Sandeep; Upadhyay, Shishir; Mantha, Anil Kumar; Dhiman, Monisha (Humana Press Inc., 2022-01-19)Oxidative stress has been implicated in various human diseases, including cancer, mainly through the generation of reactive nitrogen species (RNS), such as nitric oxide (NO), nitrite, nitroxyl, s-nitrosothiols, and reactive ... -
Oxidative stress and inflammation in cardiovascular diseases: Two sides of the same coin
Dhiman, Monisha; Thakur, Shweta; Upadhyay, Shishir; Kaur, Amandeep; Mantha, Anil K. (Springer India, 2015)Globally, the major cause of long- term disability and death is an ?epidemiologic transition? from infectious diseases and malnutrition complications to non-communicable chronic diseases like cardiovascular disease (CVD), ... -
Oxidative stress and innate immune response in A549 lung carcinoma cells
Upadhyay, Shishir (Central University of Punjab, 2014)Cancer immunology is the study of cross-talk between the immune response and cancer cells. The immune response, including the recognition of cancer-specific antigens is of particular interest as knowledge gained drives the ... -
A short review: Doxorubicin and its effect on cardiac proteins
Upadhyay, Shishir; Gupta, Kunj Bihari; Mantha, Anil Kumar; Dhiman, Monisha (Wiley-Liss Inc., 2020-12-26)Doxorubicin (DOX) is a boon for cancer-suffering patients. However, the undesirable effect�on health on vital organs, especially the heart, is a�limiting factor, resulting in an increased number of patients with cardiac ...