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Understanding the multifaceted role of ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) and its altered behaviour in human diseases
(Bentham Science Publishers B.V., 2015)Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) also known as Autotaxin, is a secreted lysophospholipase D, which hydrolyzes lysophosphatidylcholine (LPC) into Lysophosphatidic acid (LPA). LPA is the bioactive ... -
An in vitro study ascertaining the role of H2O2 and glucose oxidase in modulation of antioxidant potential and cancer cell survival mechanisms in glioblastoma U-87 MG cells
(Springer New York LLC, 2017)Glial cells protect themselves from the elevated reactive oxygen species (ROS) via developing unusual mechanisms to maintain the genomic stability, and reprogramming of the cellular antioxidant system to cope with the ... -
Oxidative stress and inflammation in cardiovascular diseases: Two sides of the same coin
(Springer India, 2015)Globally, the major cause of long- term disability and death is an ?epidemiologic transition? from infectious diseases and malnutrition complications to non-communicable chronic diseases like cardiovascular disease (CVD), ... -
Essential oils and their constituents as anticancer agents: A mechanistic view
(Hindawi Publishing Corporation, 2014)Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for ... -
Phytochemical Ginkgolide B Attenuates Amyloid- 1 - 42 Induced Oxidative Damage and Altered Cellular Responses in Human Neuroblastoma SH-SY5Y Cells
(IOS Press, 2017)Oxidative stress is an upsurge in reactive oxygen/nitrogen species (ROS/RNS), which aggravates damage to cellular components viz. lipids, proteins, and nucleic acids resulting in impaired cellular functions and neurological ... -
DNA Repair and Redox Activities and Inhibitors of Apurinic/ Apyrimidinic Endonuclease 1/Redox Effector Factor 1 (APE1/Ref-1): A Comparative Analysis and Their Scope and Limitations toward Anticancer Drug Development
(ACS Publications, 2014)The apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional enzyme involved in DNA repair and activation of transcription factors through its redox function. The evolutionarily conserved ... -
Ginkgolide B Revamps Neuroprotective Role of Apurinic/Apyrimidinic Endonuclease 1 and Mitochondrial Oxidative Phosphorylation Against Ab 25–35 -Induced Neurotoxicity in Human Neuroblastoma Cells
(Wiley, 2015)Accumulating evidence points to roles for oxidative stress, amyloid beta (Aβ), and mitochondrial dysfunction in the pathogenesis of Alzheimer's disease (AD). In neurons, the base excision repair pathway is the predominant ... -
Indian Herbs and their Therapeutic Potential against Alzheimer’s Disease and other Neurological Disorders
(Wiley, 2017)Many present-day diseases are caused by disruption of the delicate balance between the reactive oxygen/nitrogen species (ROS/RNS) produced by oxidants and their scavenging by the antioxidants in the body. Chief among them ... -
Recent developments on the structure–activity relationship studies of MAO inhibitors and their role in different neurological disorders
(Royal Society of Chemistry, 2016)Monoamine oxidase (MAO) enzyme catalyzes the oxidative deamination of xenobiotic and endogenous amines including many neurotransmitters. The MAO enzyme exists in two isoforms; MAO-A and MAO-B and these isoforms display ... -
A review on protein–protein interaction network of APE1/Ref-1 and its associated biological functions
(Wiley, 2015)Apurinic/apyrimidinic endonuclease 1 (APE1) is a classic example of functionally variable protein. Besides its well-known role in (i) DNA repair of oxidative base damage, APE1 also plays a critical role in (ii) redox ... -
Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
(Impact Journals LLC, 2016)Ionizing radiation (IR) induces highly cytotoxic double-strand breaks (DSBs) and also clustered oxidized bases in mammalian genomes. Base excision repair (BER) of bi-stranded oxidized bases could generate additional DSBs ... -
APE1: A Molecule of Focus with Neuroprotective and Anti-Cancer Properties
(OMICS Publishing Group, 2013)Apurinic/Apyrimidinic endonuclease (APE1) is a multi-functional, central enzyme of base excision repair (BER) pathway that takes care of oxidized base damage (AP sites and strand breaks) caused by both endogenous and ... -
A short review on the implications of base excision repair pathway for neurons: Relevance to neurodegenerative diseases
(Elsevier, 2014)Oxidative DNA damage results from the attack by reactive oxygen and nitrogen species (ROS/RNS) on human genome. This includes base modifications such as oxidized bases, abasic (AP) sites, and single-strand breaks (SSBs), ... -
Human apurinic/apyrimidinic endonuclease (APE1) is acetylated at DNA damage sites in chromatin, and acetylation modulates its DNA repair activity
(American Society for Microbiology, 2016)Apurinic/apyrimidinic (AP) sites, the most frequently formed DNA lesions in the genome, inhibit transcription and block replication. The primary enzyme that repairs AP sites in mammalian cells is the AP endonuclease (APE1), ... -
Understanding human thiol dioxygenase enzymes: structure to function and biology to pathology
(Wiley, 2017)Amino acid metabolism is a significant metabolic activity in humans, especially of sulphur-containing amino acids, methionine and cysteine (Cys). Cys is cytotoxic and neurotoxic in nature; hence, mammalian cells maintain ... -
Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair
(Impact Journals LLC, 2016)Apurinic/apyrimidinic (AP) sites are frequently generated in the genome by spontaneous depurination/depyrimidination or after removal of oxidized/modified bases by DNA glycosylases during the base excision repair (BER) ... -
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes
(2013)Non-coding apurinic/apyrimidinic (AP) sites in DNA form spontaneously and as DNA base excision repair intermediates are the most common toxic and mutagenic in vivo DNA lesion. For repair,APsites must be processed by 5' AP ... -
Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors
(Elsevier Masson SAS, 2017)There are around 20 Cyclin-dependent kinases (CDKs) known till date, and various research groups have reported their role in different types of cancer. The X-ray structures of some CDKs especially CDK2 was exploited in the ... -
Apert’s syndrome: study by whole exome sequencing
(Elsevier, 2017)In the present study we attempted a parent-child trio, whole exome sequencing (WES) approach to study Apert’s syndrome. Clinical characteristics of the child were noted down and WES was carried out using Ion Torrent System ... -
Effect of doping on optical properties in BiMn1−x(TE)xO3 (where x = 0.0, 0.1 and TE = Cr, Fe, Co, Zn) nanoparticles synthesized by microwave and sol-gel methods
(Springer, 2017)The structural, optical, and dielectric properties of polycrystalline BiMn1-xTExO3 (x = 0, 0.1 and TE = Cr, Fe, Co, and Zn) samples synthesized by microwave-assisted synthesis, and sol-gel techniques have been studied. It ...
