Browsing by Subject "Allosteric Regulation"
Now showing items 1-2 of 2
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Computer-aided design of negative allosteric modulators of metabotropic glutamate receptor 5 (mGluR5): Comparative molecular field analysis of aryl ether derivatives
(Elsevier Ltd, 2016)The metabotropic glutamate receptors (mGlu receptors) have emerged as attractive targets for number of neurological and psychiatric disorders. Recently, mGluR5 negative allosteric modulators (NAMs) have gained considerable ... -
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2
(American Chemical Society, 2021-11-02)The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2 protein between the high-activity and low-activity states that allow ATP and lactate production, respectively. PKM2, in its low ...