Now showing items 1-3 of 3

    • Adsorption and Activation of CO2on Small-Sized Cu-Zr Bimetallic Clusters 

      Megha; Mondal, Krishnakanta; Ghanty, Tapan K.; Banerjee, Arup (American Chemical Society, 2021-03-17)
      Adsorption and activation of CO2 is a key step in any chemical reaction, which aims to convert it to other useful chemicals. Therefore, it is important to understand the factors that drive the activation process and also ...
    • Gaussian field-based 3D-QSAR and molecular simulation studies to design potent pyrimidine-sulfonamide hybrids as selective BRAFV600E inhibitors 

      Singh, Ankit Kumar; Novak, Jurica; Kumar, Adarsh; Singh, Harshwardhan; Thareja, Suresh; Pathak, Prateek; Grishina, Maria; Verma, Amita; Yadav, Jagat Pal; Khalilullah, Habibullah; Pathania, Vikas; Nandanwar, Hemraj; Jaremko, Mariusz; Emwas, Abdul-Hamid; Kumar, Pradeep (Royal Society of Chemistry, 2022-10-21)
      The �RAS-RAF-MEK-ERK� pathway is an important signaling pathway in melanoma. BRAFV600E (70-90%) is the most common mutation in this pathway. BRAF inhibitors have four types of conformers: type I (?C-IN/DFG-IN), type II ...
    • Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase 

      Dong, Shengli; Baranwal, Somesh; Garcia, Anapatricia; Serrano-Gomez, Silvia; Eastlack, Steven; Iwakuma, Tomoo; Mercante, Donald; Mauvais-Jarvis, Franck; Alahari, Suresh K.; Dong, S.; Baranwal, S.; Garcia, A.; Serrano-Gomez, S.J.; Eastlack, S.; Iwakuma, T.; Mercante, D.; Mauvais-Jarvis, F.; Alahari, S.K. (American Society for Biochemistry and Molecular Biology Inc., 2017)
      Nischarin (Nisch) is a key protein functioning as a molecular scaffold and thereby hosting interactions with several protein partners. To explore the physiological importance of Nisch, here we generated Nisch loss-of-function ...