Browsing by Subject "Chemoresistance"
Now showing items 1-5 of 5
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Analysis of the Inhibitory Effect of hsa-miR-145-5p and hsa-miR-203a-5p on Imatinib-Resistant K562 Cells by GC/MS Metabolomics Method
(American Chemical Society, 2023-09-14)Imatinib (IM) resistance is considered to be a significant challenge in the management of chronic myeloid leukemia (CML). Previous studies have reported that hsa-miR-145-5p and hsa-miR-203a-5p can overcome IM resistance ... -
Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents
(Royal Society of Chemistry, 2023-03-03)Cancer is a major cause of deaths across the globe due to chemoresistance and lack of selective chemotherapy. Pyrido[2,3-d]pyrimidine is an emerging scaffold in medicinal chemistry having a broad spectrum of activities, ... -
miR-145-5p and miR-203a-5p overcome imatinib resistance in myelogenous leukemic cells through metabolic reprogramming
(National Institute of Science Communication and Policy Research, 2023-03-01)Imatinib is the most effective therapy for chronic myeloid leukemia (CML), but many patients eventually develop resistance to it after an initial satisfactory response. This study investigated the potential of three miRNAs ... -
Small regulatory molecules acting big in cancer: Potential role of mito-miRs in cancer
(Bentham Science Publishers, 2019)MicroRNAs [miRNAs] are short, non-coding, single stranded RNA molecules regulating gene expression of their targets at the posttranscriptional level by either degrading mRNA or by inhibiting translation. Previously, miRNAs ... -
STAT signaling as a target for intervention: from cancer inflammation and angiogenesis to non-coding RNAs modulation
(Springer Science and Business Media B.V., 2022-04-26)As a landmark, scientific investigation in cytokine signaling and interferon-related anti-viral activity, signal transducer and activator of transcription (STAT) family of proteins was first discovered in the 1990s. Today, ...