Browsing by Subject "Chromene"
Now showing items 1-3 of 3
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Gaussian field-based comparative 3D QSAR modelling for the identification of favourable pharmacophoric features of chromene derivatives as selective inhibitors of ALR2 over ALR1
(Springer, 2021-01-07)Aldehyde reductase (ALR1) and aldose reductase (ALR2) are both oxo-reductase enzymes of aldo-keto reductase (AKR) superfamily involved in several cellular processes. ALR1 plays an important role in colorectal cancer, lungs, ... -
Identification of novel indole based heterocycles as selective estrogen receptor modulator.
(Elsevier, 2018)In the present study, we have designed and synthesized indole derivatives by coalescing the indole nucleus with chromene carbonitrile and dihydropyridine nucleus. Two compounds 5c and 6d were selected from series I and II ... -
Synthetic strategies and pharmacological activities of chromene and its derivatives: An overview
(Elsevier B.V., 2022-04-07)Chromene is commonly found in nature and is considered one of the most frequently used scaffolds in heterocyclic chemistry for the designing of chemical probes for therapeutic and diagnostic purposes. The chromene nucleus ...