Browsing by Subject "Chronic Myeloid Leukemia"
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Combating TKI resistance in CML by inhibiting the PI3K/Akt/mTOR pathway in combination with TKIs: a review
(Springer, 2021-01-16)Chronic myeloid leukemia (CML), a myeloproliferative hematopoietic cancer, is caused by a genetic translocation between chromosomes 9 and 22. This translocation produces a small Philadelphia chromosome, which contains the ... -
Novel pharmacological approach for the prevention of multidrug resistance (MDR) in a human leukemia cell line
(Elsevier Ltd, 2021-06-11)Background: Drug resistance mechanisms are the regulatory factors associated with drug metabolism and drug transport to inward and outward of the target cells. Maybridge fragment (MBF) library is a collection of pharmacophore ...