Now showing items 1-7 of 7

    • Genetic signatures in ischemic stroke: Focus on aspirin resistance 

      Vasudeva, Kanika; Chaurasia, Pratibha; Singh, Sulena; Munshi, Anjana (Bentham Science Publishers B.V., 2017)
      Background and Objective: Stroke is one of the leading causes of death. There has been compelling evidence that stroke has a genetic component. Genetic variants not only influence susceptibility to stroke but have also ...
    • Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes 

      Imamura, M.; Takahashi, A.; Yamauchi, T.; Hara, K.; Yasuda, K.; Grarup, N.; Zhao, W.; Wang, X.; Huerta-Chagoya, A.; Hu, C.; Moon, S.; Long, J.; Kwak, S.H.; Rasheed, A.; Saxena, R.; Ma, R.C.W.; Okada, Y.; Iwata, M.; Hosoe, J.; Shojima, N.; Iwasaki, M.; Fujita, H.; Suzuki, K.; Danesh, J.; J?rgensen, T.; J?rgensen, M.E.; Witte, D.R.; Brandslund, I.; Christensen, C.; Hansen, T.; Mercader, J.M.; Flannick, J.; Moreno-Mac?as, H.; Burtt, N.P.; Zhang, R.; Kim, Y.J.; Zheng, W.; Singh, J.R.; Tam, C.H.T.; H (Nature Publishing Group, 2016)
      Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis ...
    • Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study 

      Sapkota, B.R.; Hopkins, R.; Bjonnes, A.; Ralhan, S.; Wander, G.S.; Mehra, N.K.; Singh, J.R.; Blackett, P.R.; Saxena, R.; Sanghera, D.K. (Elsevier Ltd, 2016)
      Vitamin D deficiency is implicated in multiple disease conditions and accumulating evidence supports that the variation in serum vitamin D (25(OH)D) levels, including deficiency, is under strong genetic control. However, ...
    • Investigating regulatory signatures of human autophagy related gene 5 (ATG5) through functional in silico analysis 

      Vij, Avni; Randhawa, Rohit; Parkash, Jyoti; Changotra, Harish; Vij, A.; Randhawa, R.; Parkash, J.; Changotra, H. (Elsevier B.V., 2016)
      Autophagy is an essential, homeostatic process which removes damaged cellular proteins and organelles for cellular renewal. ATG5, a part of E3 ubiquitin ligase-like complex (Atg12-Atg5/Atg16L1), is a key regulator involved ...
    • PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor 

      Sanghera, D.K.; Demirci, F.Y.; Been, L.; Ortega, L.; Ralhan, S.; Wander, G.S.; Mehra, N.K.; Singh, J.; Aston, C.E.; Mulvihill, J.J.; Kamboh, I.M. (2010)
      We have examined the association of 14 tagging single nucleotide polymorphisms (tagSNPs) in peroxisome proliferator activated receptor-? transcripts 1 and 2 (PPARG1 and 2) and 5 tagSNPs in adiponectin (ADIPOQ) genes for ...
    • The regulatory roles of long non-coding RNAs in the development of chemoresistance in breast cancer 

      Malhotra, Akshay; Jain, Manju; Prakash, Hridayesh; Vasquez, Karen M.; Jain, Aklank; Malhotra, A.; Jain, M.; Prakash, H.; Vasquez, K.M.; Jain, A. (Impact Journals LLC, 2017)
      Chemoresistance is one of the major hurdles in the treatment of breast cancer, which limits the effect of both targeted and conventional therapies in clinical settings. Therefore, understanding the mechanisms underpinning ...
    • Role of Quorum Sensing in the Survival of Rhizospheric Microbes 

      Rathi, Manohari; Manchanda, Geetanjali; Singh, Raghvendra Pratap (Springer Nature, 2022-01-01)
      Quorum sensing (QS) signaling is a cell-to-cell communication or coordination at microbial population level. However, the ecological role of QS in complex or multi-species communities, principally in the milieu of community ...