Browsing by Subject "Glycolysis"
Now showing items 1-5 of 5
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In Silico Identification of Novel Natural Inhibitors Of Carbohydrate Metabolic Pathway In Cancer Cells
(Central University of Punjab, 2018)Carbohydrate metabolism in cancer cells is linked to the 'Warburg Effect' which states that, under aerobic conditions, cancer cells metabolize approximately ten fold more glucose to lactate in a given time than normal ... -
Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4
(BioMed Central Ltd, 2021-11-27)Background and objectives: MicroRNA (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNA (mitomiR). Albeit mitomiRs have been shown to modulate gene expression, their functional ... -
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2
(American Chemical Society, 2021-11-02)The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2 protein between the high-activity and low-activity states that allow ATP and lactate production, respectively. PKM2, in its low ... -
A short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiforme
(Springer, 2021-03-02)Pyruvate kinase (PK) catalyzes the last irreversible reaction of glycolysis pathway, generating pyruvate and ATP, from Phosphoenol Pyruvate (PEP) and ADP precursors. In mammals, four different tissue-specific isoforms (M1, ... -
A short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiforme
(Springer, 2021-03-02)Pyruvate kinase (PK) catalyzes the last irreversible reaction of glycolysis pathway, generating pyruvate and ATP, from Phosphoenol Pyruvate (PEP) and ADP precursors. In mammals, four different tissue-specific isoforms (M1, ...