Browsing by Subject "Molecular dynamics simulation"
Now showing items 1-4 of 4
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A candidate triple-negative breast cancer vaccine design by targeting clinically relevant cell surface markers: an integrated immuno and bio-informatics approach
(Springer Science and Business Media Deutschland GmbH, 2022-02-20)Triple-negative breast cancer (TNBC) is an aggressive, metastatic/invasive sub-class of breast cancer (BCa). Cell surface protein-derived multi-epitope vaccine-mediated targeting of TNBC cells could be a better strategy ... -
Discovery of differentially expressed novel miRNAs in breast normal cells and their putative targets
(Springer, 2023-01-21)MicroRNAs (miRNAs) play critical role in normal breast development and their altered expression may lead to breast cancer. Identification of new miRNAs allows us to understand the normal physiological process and associated ... -
Identification of Novel Indole Derivatives as Potent ?-Amylase Inhibitors for the Treatment of Type-II Diabetes Using in-Silico Approaches
(AMG Transcend Association, 2022-04-09)The ?-amylase is regarded as a promising drug target for diabetes mellitus-type II. Hence, inhibiting ?-amylase activity is a potential drug discovery approach for treating this chronic metabolic disorder. The present study ... -
A study of mechanistic mapping of novel SNPs to male breast cancer
(Humana Press Inc., 2019)Alterations in BRCA2, PALB2, CHEK2, and p53 genes have been identified for their association with male breast cancer in various studies. The incidence of male breast cancer in India is consistent with its global rate. The ...