Browsing by Subject "Natural products"
Now showing items 1-10 of 12
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Antitubercular drugs: possible role of natural products acting as antituberculosis medication in overcoming drug resistance and drug-induced hepatotoxicity
(Springer Science and Business Media Deutschland GmbH, 2023-09-04)Mycobacterium tuberculosis (Mtb) is a pathogenic bacterium which causes tuberculosis (TB). TB control programmes are facing threats from drug resistance. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb ... -
Bulbine frutescens phytochemical inhibits notch signaling pathway and induces apoptosis in triple negative and luminal breast cancer cells
(Elsevier Inc., 2019)Breast cancer (BCa) is the most commonly diagnosed lethal cancer in women worldwide. Notch signaling pathway is directly linked to BCa recurrence and aggressiveness. Natural remedies are becoming a prime choice to overcome ... -
Current therapeutic modalities and chemopreventive role of natural products in liver cancer: Progress and promise
(Baishideng Publishing Group Inc, 2023-01-15)Liver cancer is a severe concern for public health officials since the clinical cases are increasing each year, with an estimated 5-year survival rate of 30%�35% after diagnosis. Hepatocellular carcinoma (HCC) constitutes ... -
Exploring the magic bullets to identify Achilles� heel in SARS-CoV-2: Delving deeper into the sea of possible therapeutic options in Covid-19 disease: An update
(Elsevier Ltd, 2020-11-27)The symptoms associated with Covid-19 caused by SARS-CoV-2 in severe conditions can cause multiple organ failure and fatality via a plethora of mechanisms, and it is essential to discover the efficacious and safe drug. For ... -
Historical Perspective of Drug Discovery and Development
(Springer Singapore, 2021-02-18)Historically ever since the existence of humans on this planet the process of drug discovery was started by trial and error method. Initially they tested the natural products on self to understand the effects. Serendipity ... -
Natural Products as an Alternative Therapy for Brain Tumors: From Bench To Bedside
(Springer Singapore, 2022-09-28)Incremental elevation in the trends of a brain tumor in recent years accounts for 5% adult population, whereas the number exceeds 70% in the case of children. Evidence reveals an eventual metastasize of 20%-30% of malignant ... -
Natural products as multidrug resistance modulators in cancer
(Elsevier, 2019)Cancer is a prominent cause of death globally. Currently, many drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors acquiring resistance to chemotherapy ... -
P53-mediated anticancer activity of Citrullus colocynthis extracts
(Bentham Science Publishers, 2019)Background: Current anticancer therapeutics comes with significant side effects and thus focus is shifting towards minimizing the side effects or to avoid the disease altogether. Thus, various natural products are being ... -
Probing the molecular mechanisms of ?-synuclein inhibitors unveils promising natural candidates through machine-learning QSAR, pharmacophore modeling, and molecular dynamics simulations
(Institute for Ionics, 2023-07-18)Parkinson�s disease is characterized by a multifactorial nature that is linked to different pathways. Among them, the abnormal deposition and accumulation of ?-synuclein fibrils is considered a neuropathological hallmark ... -
Protective role of natural products and bioactive compounds in multiple sclerosis
(Elsevier, 2023-06-16)Multiple sclerosis (MS), a chronic multifactorial disease characterized by progressive demyelination and neurodegeneration, is rising rapidly in young adults. The pathology of the disease is not yet understood completely. ...