Browsing by Subject "Oxidative Stress"
Now showing items 1-10 of 19
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Assessment of Extract of Syzygium cumini Against Doxorubicin Induced Cardiotoxicity
(Central University of Punjab, 2018)For the past four decades, doxorubicin (DOX) has been used to treat cancer, mainly solid tumours and haematological malignancies. However, clinical community is greatly concerned regarding the administration of this as DOX ... -
ASSOCIATION OF OXIDATIVE STRESS WITH CYP1A2, CYP3A4, CYP2B6 AND PON1 GENETIC POLYMORPHISM IN AGRICULTURAL COMMUNITY OF BATHINDA
(Central University of Punjab, 2018)The aim of present study is to evaluate the association of oxidative stress with CYP1A2, CYP3A4, CYP2B6 and PON1 genetic variation in the pesticide exposed (occupationally) population. The present study demonstrated that ... -
Association of serum homocysteine and hs-CRP with idiopathic generalised epilepsy and duration of antiepileptic drug therapy
(Journal of Clinical and Diagnostic Research, 2018)Introduction: Several human and experimental studies have revealed that chronic inflammation may play a vital role in neurodegenerative processes including epilepsy. There is accumulating evidence that inflammatory processes ... -
Effect of amyloid beta (25-35) peptide on mitochondrial respiratiory function in neuroral cells over expressing ape1
(Central University of Punjab, 2014)Alzheimer's disease (AD) is an important public health problem which affects millions of people worldwide. The major pathological hallmarks associated with AD are the accumulation of amyloid beta (A?) in senile plaques and ... -
Effect of lead on oxidative status, antioxidative response and metal accumulation in Coronopus didymus
(Elsevier Masson SAS, 2016)A screenhouse experiment was conducted to assay the effect of Lead (Pb) on oxidative status, antioxidative response and metal accumulation in Coronopus didymus after 6 weeks. Results revealed a good Pb tolerance and ... -
Evaluation of amyloid beta (aβ)-induced Mitochondrial dysfunction: Neuroprotective role of Apurinic/apyrimidinic endonuclease (ape1) Via its interaction with cysteamine Dioxygenase (ado)
(Central University of Punjab, 2020)Oxidative stress and damage to mitochondrial DNA during the aging process can impair mitochondrial energy metabolism and ion homeostasis in neurons, ultimately leading to neurodegeneration. Themain pathway for repairing ... -
Ganoderic acid targeting multiple receptors in cancer: in silico and in vitro study
(Springer Netherlands, 2016)Receptor tyrosine kinases (RTKs) are transmembrane high-affinity surface receptors responsible for cell migration, adhesion, apoptosis, metabolism, and cell proliferation activities in various cancers. Minute aberration ... -
Innate Immune Responses and Antioxidant/Oxidant Imbalance Are Major Determinants of Human Chagas Disease
(Public Library of Science, 2013)Background:We investigated the pathological and diagnostic role of selected markers of inflammation, oxidant/antioxidant status, and cellular injury in human Chagas disease.Methods:Seropositive/chagasic subjects characterized ... -
Investigation of combined genotoxic effect of pesticides on cancer cell lines
(Central University of Punjab, 2013)The use of pesticides in agriculture sector is increasing widely to alleviate crop loss due to pests. To combat problem of pest, various types of pesticides are widely used, out of which insecticide are majorly used. In ... -
MnSOD tg Mice Control Myocardial Inflammatory and Oxidative Stress and Remodeling Responses Elicited in Chronic Chagas Disease
(American Heart Association, 2013)Background We utilized genetically modified mice equipped with a variable capacity to scavenge mitochondrial and cellular reactive oxygen species to investigate the pathological significance of oxidative stress in Chagas ...