Browsing by Subject "drug design"
Now showing items 1-4 of 4
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Molecular dynamics and 3D-QSAR studies on indazole derivatives as HIF-1? inhibitors
(Taylor and Francis Ltd., 2022-03-23)Hypoxia-inducible factor (HIF) is a transcriptional factor which plays a crucial role in tumour metastasis thereby responsible for development of various forms of cancers. Indazole derivatives have been reported in the ... -
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2
(American Chemical Society, 2021-11-02)The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2 protein between the high-activity and low-activity states that allow ATP and lactate production, respectively. PKM2, in its low ... -
PROTAC�ing oncoproteins: targeted protein degradation for cancer therapy
(BioMed Central Ltd, 2023-03-30)Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited. Resistance to these therapies is often related to adaptive changes in the target ... -
Targeting the Epidermal Growth Factor Receptor with Molecular Degraders: State-of-the-Art and Future Opportunities
(American Chemical Society, 2023-02-22)Epidermal growth factor receptor (EGFR) is an oncogenic drug target and plays a critical role in several cellular functions including cancer cell growth, survival, proliferation, differentiation, and motility. Several ...
