Browsing by Subject "medicinal chemistry"

Now showing items 1-3 of 3

    • Medicinal Chemistry Aspects of Isoxazole Analogues as Anti-tubercular Agents 

      Singh, Harshwardhan; Anila, Kumari V. S.; Singh, Ankit Kumar; Kumar, Adarsh; Kumar, Pradeep (Bentham Science Publishers, 2023-10-11)
      Tuberculosis (TB) is the major cause of mortality around the world and one of the most common diseases linked to AIDS. Due to the emergence of multi-drug resistance, extensive drug resistance, and total drug resistance ...

    • A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2 

      Arora, Sahil; Joshi, Gaurav; Chaturvedi, Anuhar; Heuser, Michael; Patil, Santoshkumar; Kumar, Raj (American Chemical Society, 2021-11-02)
      The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2 protein between the high-activity and low-activity states that allow ATP and lactate production, respectively. PKM2, in its low ...

    • PROTAC�ing oncoproteins: targeted protein degradation for cancer therapy 

      Kelm, Jeremy M.; Pandey, Deepti S.; Malin, Evan; Kansou, Hussein; Arora, Sahil; Kumar, Raj; Gavande, Navnath S. (BioMed Central Ltd, 2023-03-30)
      Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited. Resistance to these therapies is often related to adaptive changes in the target ...