Browsing by Subject "metabolism"
Now showing items 1-8 of 8
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Comparative metabolic profiling of vetiver (Chrysopogon zizanioides) and maize (Zea mays) under lead stress
(Elsevier Ltd, 2018)Lead (Pb) contamination of residential soils in United States is attributed to use of Pb based paints prior to 1978 and their deterioration and accumulation in surface soils. Exposure to Pb due to ingestion and inhalation ... -
CRISPR/Cas9 mediated mutagenesis of MORE AXILLARY GROWTH 1 in tomato confers�resistance to root�parasitic weed Phelipanche aegyptiaca
(Nature Research, 2021-02-17)Root parasitic weeds infect numerous economically important crops, affecting total yield quantity and quality. A lack of an efficient control method limits our ability to manage newly developing and more virulent races of ... -
Dopamine, sleep, and neuronal excitability modulate amyloid-?-mediated forgetting in Drosophila
(Public Library of Science, 2021-10-07)Alzheimer disease (AD) is one of the main causes of age -related dementia and neurodegeneration. However, the onset of the disease and the mechanisms causing cognitive defects are not well understood. Aggregation of ... -
L-Methionine supplementation attenuates high-fat fructose diet-induced non-alcoholic steatohepatitis by modulating lipid metabolism, fibrosis, and inflammation in rats
(Royal Society of Chemistry, 2022-03-31)Recently, the protective effects of a methionine-rich diet on hepatic oxidative stress and fibrosis have been suggested but not adequately studied. We, therefore, hypothesized that l-methionine supplementation would ... -
PROTAC�ing oncoproteins: targeted protein degradation for cancer therapy
(BioMed Central Ltd, 2023-03-30)Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited. Resistance to these therapies is often related to adaptive changes in the target ... -
Role of Metabolism and Metabolic Pathways in Prostate Cancer
(MDPI, 2023-01-26)Prostate cancer (PCa) is the common cause of death in men. The pathophysiological factors contributing to PCa are not well known. PCa cells gain a protective mechanism via abnormal lipid signaling and metabolism. PCa cells ... -
Targeting the Epidermal Growth Factor Receptor with Molecular Degraders: State-of-the-Art and Future Opportunities
(American Chemical Society, 2023-02-22)Epidermal growth factor receptor (EGFR) is an oncogenic drug target and plays a critical role in several cellular functions including cancer cell growth, survival, proliferation, differentiation, and motility. Several ... -
Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion
(Oxford University Press, 2022-01-28)Invading tumor cells develop membrane protruding structures called invadopodia to invade and metastasize. Previously, we have reported the role of formin-binding protein-17 (FBP17) in extracellular matrix degradation and ...