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Association of Serum Trace Elements and Minerals with Genetic Generalized Epilepsy and Idiopathic Intractable Epilepsy

dc.contributor.authorPrasad, D.K.V.
dc.contributor.authorShaheen,Uzma
dc.contributor.authorSatyanarayana,U.
dc.contributor.authorPrabha, T. Surya
dc.contributor.authorJyothy, Akka|Munshi, Anjana
dc.contributor.authorPrasad, D.K.V.
dc.contributor.authorShaheen, U.
dc.contributor.authorSatyanarayana, U.
dc.contributor.authorSurya Prabha, T.
dc.contributor.authorJyothy, A.
dc.contributor.authorMunshi, Anjana
dc.date.accessioned2018-07-10T07:30:30Z
dc.date.available2018-07-10T07:30:30Z
dc.date.issued2014
dc.identifier.citationPrasad, D. K. V., Shaheen, U., Satyanarayana, U., Surya Prabha, T., Jyothy, A., & Munshi, A. (2014). Association of Serum Trace Elements and Minerals with Genetic Generalized Epilepsy and Idiopathic Intractable Epilepsy. Neurochemical Research, 39(12), 2370-2376. doi: 10.1007/s11064-014-1439-3en_US
dc.identifier.issn3643190
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/1051
dc.description.abstractCertain minerals and trace elements are essential for the development of healthy nervous system. Altered serum levels of these elements may lead to the development of various diseases including epilepsy. The present study was designed to evaluate the association of serum calcium, magnesium, zinc and copper in the development of genetic generalized epilepsy [GGE; erstwhile known as idiopathic generalized epilepsy (IGE)] as well as idiopathic intractable epilepsy (IIE), in which seizures persist despite treatment with at least two or three antiepileptic drugs tolerated at reasonable dosage. 200 GGE patients and equal number of healthy controls were recruited for study with their written informed consent. The patients were further divided into responders and non-responders based on their response to antiepileptic drugs. Copper and zinc levels were assayed by atomic absorption spectrophotometer whereas calcium and magnesium were analyzed by Human Star 600 fully automated biochemistry analyzer. The patients with GGE had significant low levels of calcium, magnesium and zinc (1.85???0.33, 0.69???0.13?mmol/L and 11.33???3.32??mol/L respectively) and the corresponding values for controls were 2.27???0.22, 0.89???0.15, 12.71???3.24 (p?<?0.05). Significant high levels of copper were found in patients as compared to controls (26.69???8.79??mol/L; 16.64???3.64) (p?<?0.05). Significantly decreased levels of zinc were noted in non-responders (10.38???2.99) compared to responders (12.62???3.30) (p?<?0.05). No significant difference was observed in serum calcium, magnesium and copper levels between responders and non-responders. In conclusion, low levels of calcium, magnesium, zinc and high levels of copper were found to be associated with GGE. Further, the patients with IIE were also found to have low levels of zinc. ? 2014, Springer Science+Business Media New York.en_US
dc.language.isoenen_US
dc.publisherSpringer New York LLCen_US
dc.subjectcalcium; carbamazepine; copper; etiracetam; lamotrigine; magnesium; phenytoin; valproic acid; zinc; mineral; trace element; adolescent; Article; atomic absorption spectrometry; calcium blood level; comparative study; controlled study; copper blood level; drug tolerability; female; generalized epilepsy; groups by age; human; idiopathic disease; idiopathic intractable epilepsy; India; intractable epilepsy; magnesium blood level; major clinical study; male; trace metal blood level; zinc blood levelen_US
dc.titleAssociation of Serum Trace Elements and Minerals with Genetic Generalized Epilepsy and Idiopathic Intractable Epilepsyen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s11064-014-1439-3
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs11064-014-1439-3
dc.title.journalNeurochemical Research


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