| dc.contributor.author | Das, Satrupa | |
| dc.contributor.author | Roy, Sitara | |
| dc.contributor.author | Kaul, Subhash | |
| dc.contributor.author | Jyothy, Akka | |
| dc.contributor.author | Munshi, Anjana | |
| dc.date.accessioned | 2018-07-10T07:30:30Z | |
| dc.date.available | 2018-07-10T07:30:30Z | |
| dc.date.issued | 2014 | |
| dc.identifier.citation | Das, S., Roy, S., Kaul, S., Jyothy, A., & Munshi, A. (2014). E-selectin gene (S128R) polymorphism in hemorrhagic stroke: Comparison with ischemic stroke. Neuroscience Letters, 581, 125-128. doi: 10.1016/j.neulet.2014.08.032 | en_US |
| dc.identifier.issn | 3043940 | |
| dc.identifier.uri | http://kr.cup.edu.in/handle/32116/1055 | |
| dc.description.abstract | Increasing evidence suggests that genetic variation in inflammatory genes plays a pivotal role in pathogenesis of stroke. The aim of the present study was to evaluate the association of E-selectin S128R polymorphism with hemorrhagic stroke and also to evaluate the genotypic and allelic variation with ischemic stroke in a South Indian population from Andhra Pradesh. In this study, we recruited 250 hemorrhagic stroke patients along with 250 age and sex matched controls. The genotypes were determined using PCR-RFLP method and the strength of association between genotypes and hemorrhagic stroke was determined by odds ratio with 95% confidence interval (CI) and chi-square analysis. Allelic and genotypic frequencies of the polymorphism differed significantly between hemorrhagic stroke patients and controls (p < 0.001). Significant association was also found following dominant (p < 0.001) and co-dominant (p < 0.001) models. On comparing the genotypic and allelic frequencies between ischemic and hemorrhagic stroke significant difference was found between the two stroke types (p < 0.001). In conclusion, we found the AC genotype to be a significant risk factor for hemorrhagic stroke and we also found significant differences in AC genotype and C allele among the two stroke types. The genotypic and allelic variation between the ischemic and hemorrhagic stroke, suggests that E-selectin S128R mediated amplification of leukocytes onto endothelial cells, leading to secondary damage of brain cells is more pronounced in hemorrhagic stroke. ? 2014 Elsevier Ireland Ltd. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | Elsevier Ireland Ltd | en_US |
| dc.subject | endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule 1; SELE protein, human; adult; Article; brain hemorrhage; brain ischemia; comparative study; controlled study; disease association; DNA polymorphism; female; gene frequency; genotype; human; major clinical study; male; polymerase chain reaction; restriction fragment length polymorphism; brain hemorrhage; brain ischemia; cerebrovascular accident; genetic association; genetic polymorphism; genetic predisposition; ge | en_US |
| dc.title | E-selectin gene (S128R) polymorphism in hemorrhagic stroke: Comparison with ischemic stroke | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | 10.1016/j.neulet.2014.08.032 | |
| dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S0304394014006946 | |
| dc.title.journal | Neuroscience Letters | |
