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Synthesis, biological evaluation and molecular modeling studies of phenyl-/benzhydrylpiperazine derivatives as potential MAO inhibitors
(Academic Press Inc., 2018)
Monoamine oxidase inhibitors (MAOIs) are potential drug candidates for the treatment of various neurological disorders like Parkinson's disease, Alzheimer's disease and depression. In the present study, two series of ...
APE1 modulates cellular responses to organophosphate pesticide-induced oxidative damage in non-small cell lung carcinoma A549 cells
(Springer New York LLC, 2018)
Monocrotophos (MCP) and chlorpyrifos (CP) are widely used organophosphate pesticides (OPPs), speculated to be linked with human pathologies including cancer. Owing to the fact that lung cells are most vulnerable to the ...
Anticancer activity of dihydropyrazolo[1,5-c]quinazolines against rat C6 glioma cells via inhibition of topoisomerase II
(Wiley-VCH Verlag, 2018)
The design and synthesis of dihydropyrazolo[1,5-c]quinazolines (1a?h) as human topoisomerase II (TopoII) catalytic inhibitors are reported. The compounds were investigated for their antiproliferative activity against the ...
Pseudomonas aeruginosa quorum sensing molecule N-3-oxo-dodecanoyl-L-homoserine lactone activates human platelets through intracellular calcium-mediated ROS generation
(Elsevier GmbH, 2018)
Pseudomonas aeruginosa, an opportunistic pathogen release N-3-oxo-dodecanoyl-L-homoserine lactone (3-oxo-C12HSL) and N-butyryl-L-homoserine lactone (C4-HSL) quorum sensing (QS) molecules to regulate various virulence factors ...
To Study the Anti-Proliferative Effect of Pirfenidone via MAP Kinase Signaling Pathway
(Central University of Punjab, 2018)
Pirfenidone is a pyridine chemical compound used as a therapeutic drug used for the treatment of Idiopathic Pulmonary Fibrosis (IPF). The characteristic feature of the fibrosis is the deposition of extracellular matrix ...
Role of curcumin on monoamine oxidase(MAO) enzyme expression and activity against Amyloid Beta (A?)-induced oxidative stress in human glioblastoma U-87 MG cell.
(Central University of Punjab, 2018)
Glioblastoma (GBM) is the most common brain tumor in humans. The major factor responsible for its progression is oxidative stress. Oxidative stress leads to disruption of signaling pathways and damage to cells and tissues. ...
Development of lactadherin based electrochemical biosensor for the detection of platelet microvesicles
(Central University of Punjab, 2018)
Platelet derived microvesicles (PMVs) are the most abundant membrane vesicles in
the blood having a potent pro-inflammatory effect, promote coagulation and affect
vascular function which are involved in the pathogenesis ...
To check the glioprotective effect of Withaferin A on C6 Glioma cell Culture challenged with Kainic Acid
(Central University of Punjab, 2018)
Last many years perception of glial cell function in CNS has been changed. In fact abnormalities in glial cells also contribute to various disorders. Glutamate induced excitotoxicity attributed to various CNS related ...
Expression Study of Long non-coding RNA SCAL1 and GAS6-AS1 in Lung cancer Cell line A549 Compared to IMR-90
(Central University of Punjab, 2018)
Lung cancer is the fatal type of cancer owing to maximum number death worldwide. Despite the advances in clinical and experimental setup lung cancer still is the deadliest type of cancer wherein survival rate is as low as ...
Neuro-Protective Role Of Ginkgolide B In A?induced Neurodegeneration And Ache Enzyme Activity In Human Neuroblastoma Sh-Sy5Y Cells
(Central University of Punjab, 2018)
Ginkgolide B (GB) is being used as medicine in China for treating neurodegenerative diseases for a long time. Its neuroprotective role is getting well established. Alzheimer's disease (AD) is a neurodegenerative disease ...