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Understanding human thiol dioxygenase enzymes: structure to function and biology to pathology
(Wiley, 2017)
Amino acid metabolism is a significant metabolic activity in humans, especially of sulphur-containing amino acids, methionine and cysteine (Cys). Cys is cytotoxic and neurotoxic in nature; hence, mammalian cells maintain ...
Molecular mechanisms of action of tocotrienols in cancer: Recent trends and advancements
(MDPI AG, 2019)
Tocotrienols, found in several natural sources such as rice bran, annatto seeds, and palm oil have been reported to exert various beneficial health promoting properties especially against chronic diseases, including cancer. ...
Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement
(Academic Press, 2020)
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is an ester of epigallocatechin and gallic acid. EGCG, abundantly found in tea, is a polyphenolic flavonoid that has the potential to affect human ...
Molecular mechanisms of action of genistein in cancer: Recent advances
(Frontiers Media S.A., 2019)
Background: Genistein is one among the several other known isoflavones that is found in different soybeans and soy products. The chemical name of genistein is 4?,5,7-trihydroxyisoflavone. Genistein has drawn attention of ...
Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement
(Academic Press, 2020-05-24)
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is an ester of epigallocatechin and gallic acid. EGCG, abundantly found in tea, is a polyphenolic flavonoid that has the potential to affect human ...
Herbal Remedies for Improving Cancer Treatment Through Modulation of Redox Balance
(Springer Singapore, 2022-09-28)
The redox modulation induced by oxidative stress is one of the major cause of the metabolic and inflammatory disorders including cancer. The reactive oxygen species (ROS) produced by various sources in the cell shift the ...
NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target
(Elsevier Ireland Ltd, 2021-06-29)
Notch signaling, an evolutionarily conserved signaling cascade, is critical for normal biological processes of cell differentiation, development, and homeostasis. Deregulation of the Notch signaling pathway has been ...
Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection
(Neoplasia Press, Inc., 2022-12-05)
Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore safer and more effective molecules to ...
Recent advances in understanding brain cancer metabolomics: a review
(Springer, 2023-07-10)
Regardless of the significant progress made in surgical techniques and adjuvant therapies, brain tumors are a major contributor to cancer-related morbidity and mortality in both pediatric and adult populations. Gliomas ...