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A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity

dc.contributor.authorBeen, L.F.
dc.contributor.authorHatfield, J.L.
dc.contributor.authorShankar, A.
dc.contributor.authorAston, C.E.
dc.contributor.authorRalhan, S.
dc.contributor.authorWander, G.S.
dc.contributor.authorMehra, N.K.
dc.contributor.authorSingh, J.R.
dc.contributor.authorMulvihill, J.J.
dc.contributor.authorSanghera, D.K.
dc.date.accessioned2018-07-14T01:18:32Z
dc.date.available2018-07-14T01:18:32Z
dc.date.issued2012
dc.identifier.citationBeen, L. F., Hatfield, J. L., Shankar, A., Aston, C. E., Ralhan, S., Wander, G. S., . . . Sanghera, D. K. (2012). A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity. Nutrition, Metabolism and Cardiovascular Diseases, 22(11), 944-951. doi: 10.1016/j.numecd.2011.01.006en_US
dc.identifier.issn9394753
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/1215
dc.description.abstractTwo common variants (rs1387153, rs10830963) in MTNR1B have been reported to have independent effects on fasting blood glucose (FBG) levels with increased risk to type 2 diabetes (T2D) in recent genome-wide association studies (GWAS). In this investigation, we report the association of these two variants, and an additional variant (rs1374645) within the GWAS locus of MTNR1B with FBG, 2h glucose, insulin resistance (HOMA IR), ?-cell function (HOMA B), and T2D in our sample of Asian Sikhs from India. Our cohort comprised 2222 subjects [1201 T2D, 1021 controls]. None of these SNPs was associated with T2D in this cohort. Our data also could not confirm association of rs1387153 and rs10830963 with FBG phenotype. However, upon stratifying data according to body mass index (BMI) (low ? 25 kg/m2 and high > 25 kg/m2) in normoglycemic subjects (n = 1021), the rs1374645 revealed a strong association with low FBG levels in low BMI group (? = -0.073, p = 0.002, Bonferroni p = 0.01) compared to the high BMI group (? = 0.015, p = 0.50). We also detected a strong evidence of interaction between rs1374645 and BMI with respect to FBG levels (p = 0.002). Our data provide new information about the significant impact of another MTNR1B variant on FBG levels that appears to be modulated by BMI. Future confirmation on independent datasets and functional studies will be required to define the role of this variant in fasting glucose variation. ? 2011.en_US
dc.language.isoen_USen_US
dc.subjectMelatonin 1 Receptoren_US
dc.subjectMtnr1B Protein, Humanen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAsianen_US
dc.subjectBlooden_US
dc.subjectBody Massen_US
dc.subjectCohort Analysisen_US
dc.subjectDiet Restrictionen_US
dc.subjectDna Sequenceen_US
dc.subjectFemaleen_US
dc.subjectGene Frequencyen_US
dc.subjectGene Locusen_US
dc.subjectGenetic Associationen_US
dc.subjectGeneticsen_US
dc.subjectGenotypeen_US
dc.subjectGlucose Blood Levelen_US
dc.subjectHumanen_US
dc.subjectIndiaen_US
dc.subjectInsulin Resistanceen_US
dc.subjectMaleen_US
dc.subjectMetabolismen_US
dc.subjectMiddle Ageden_US
dc.subjectNon Insulin Dependent Diabetes Mellitusen_US
dc.subjectObesityen_US
dc.subjectRisk Factoren_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAsian Continental Ancestry Groupen_US
dc.subjectBlood Glucoseen_US
dc.subjectBody Mass Indexen_US
dc.subjectCohort Studiesen_US
dc.subjectDiabeten_US
dc.titleA low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesityen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.numecd.2011.01.006
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0939475311000226?via%3Dihub
dc.title.journalNutrition, Metabolism and Cardiovascular Diseases


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