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Association of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi population

dc.contributor.authorAlharbi, Khalid Khalaf
dc.contributor.authorKhan, Imran Ali
dc.contributor.authorMunshi, Anjana
dc.contributor.authorAlharbi, Fawiziah Khalaf
dc.contributor.authorAl-Sheikh, Yazeed
dc.contributor.authorAlnbaheen, May Salem
dc.date.accessioned2018-07-14T01:18:35Z
dc.date.available2018-07-14T01:18:35Z
dc.date.issued2014
dc.identifier.citationAlharbi, K. K., Khan, I. A., Munshi, A., Alharbi, F. K., Al-Sheikh, Y., & Alnbaheen, M. S. (2014). Association of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi population. Endocrine, 47(2), 472-477. doi: 10.1007/s12020-014-0177-2en_US
dc.identifier.issn1355008X
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/1245
dc.description.abstractType 2 diabetes mellitus (T2DM) is a chronic degenerative disease, phenotypically and genetically heterogeneous, characterized by high levels of glucose and metabolic complications. Insulin receptor substrate 1 (IRS-1) plays a key role in the insulin-stimulated signal transduction pathway. A glycine-to-arginine substitution at codon 972 (G972R) (rs1801278) in the IRS-1 gene has been associated with impaired insulin action. Another SNP rs2943641 in the IRS-1 gene has been found to be associated with T2DM and insulin resistance in genome-wide association studies. The aim of the present study was to evaluate whether rs1801278 and rs2943641 are associated with increased risk of T2DM in the Saudi population. The study included 376 T2DM cases and 380 healthy controls. Genomic DNA was isolated using a commercially available kit supplied by Norgen Biotech Corp. Genotyping was performed by PCR and RFLP analysis. There was a significant difference in the genotypic distribution as well as allelic frequency between the T2DM cases and controls in case of both the polymorphisms for rs1801278 (1.752, 95?% CI 1.002?3.121; p?=?0.04), and for rs2943641 (OR?=?1.482, 95?% CI 1.176?1.867; p?=?0.001). In conclusion, both the (rs1801278 and rs2943641) polymorphisms are associated with T2DM in the Saudi population. ? 2014, Springer Science+Business Media New York.en_US
dc.language.isoenen_US
dc.publisherHumana Press Inc.en_US
dc.subjectGlucoseen_US
dc.subjectHigh Density Lipoprotein Cholesterolen_US
dc.subjectInsulinen_US
dc.subjectInsulin Receptor Substrate 1en_US
dc.subjectLow Density Lipoprotein Cholesterolen_US
dc.subjectTriacylglycerolen_US
dc.subjectInsulin Receptor Substrateen_US
dc.subjectIrs1 Protein, Humanen_US
dc.subjectAdulten_US
dc.subjectAllele Body Massen_US
dc.subjectControlled Studyen_US
dc.subjectDiastolic Blood Pressureen_US
dc.subjectDisease Associationen_US
dc.subjectFemaleen_US
dc.subjectGene Frequencyen_US
dc.subjectGenetic Associationen_US
dc.subjectGenetic Risken_US
dc.subjectGenetic Variabilityen_US
dc.subjectGenotypeen_US
dc.subjectGlucose Blood Levelen_US
dc.subjectHip Circumferenceen_US
dc.subjectHomeostasis Model Assessment Insulin Resistanceen_US
dc.subjectHumanen_US
dc.subjectInsulin Resistanceen_US
dc.subjectIrs 1en_US
dc.titleAssociation of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi populationen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s12020-014-0177-2
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs12020-014-0177-2
dc.title.journalEndocrine


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