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Oxidative Stress in Invertebrate Systems
(InTech, 2016)
Invertebrates have been valuable research models in the discovery of many scientific principles owing to the numerous advantages they provide. Throughout the life cycle, many of them thrive in pathogen-rich environments, ...
Biological/Biosimilar Drugs: A New Hope for Better and Low Cost Treatment
(Juniper Publishers, 2016)
Biological and biosimilar drugs
Medicines that are derived from living cells/organisms are
known as biological medicines. They consist of of highly complex
molecular entities difficult to characterize. Certain degree ...
Association of MTHFR (C677T) Gene Polymorphism With Breast Cancer in North India
(Sage, 2016)
Background
Breast cancer is one of the most common malignancies in women and is associated with a variety of risk factors. The functional single-nucleotide polymorphism (SNP) C677T in the gene encoding 5,10-methylenetet ...
D Allele Frequency in Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme (ACE) Gene is Associated with Development of Breast Cancer Risk in Indian Women
(Bentham Science, 2016)
Aims: Breast cancer is the second most common cancer in the world and, by far, the most frequent cancer among women. Scientific literature has hypothesized the association of ACE I/D polymorphism with breast cancer for ...
Novel Wnt and Notch Signaling Natural Inhibitors as Double Edged Sword Against Cancer War: An approach Towards Computer Based Drug Design
(Juniper Publishers, 2016)
Cancer is a group of disease characterized by the uncontrolled growth and spread of abnormal cells which may lead to death. According to
a report by GLOBOCAN the number of new cancer cases would increase to 19.3 million ...
Geminin as an Emerging Anticancer Drug Target
(Juniper Publishers, 2016)
For normal cell division, one time replication origin firing is
mandatory. The mutual interaction and levels of Cdt1 and geminin
(GMNN) proteins are known to be involved in this regulatory
mechanism. Imbalance between these ...
Geminin a multi task protein involved in cancer pathophysiology and developmental process: A review
(Elsevier B.V., 2016)
DNA replicates in a timely manner with each cell division. Multiple proteins and factors are involved in the initiation of DNA replication including a dynamic interaction between Cdc10-dependent transcript (Cdt1) and Geminin ...
Maps for when the living gets tough : Maneuvering through a hostile energy landscape
(Elsevier, 2016)
With genome sequencing of thousands of organisms, a scaffold has become available for data integration: molecular information can now be organized by attaching it to the genes and their gene-expression products. It is ...
Characterization of WY 14,643 and its complex with Aldose reductase
(Nature Publishing Group, 2016)
The peroxisome proliferator, WY 14,643 exhibits a pure non-competitive inhibition pattern in the aldehyde reduction and in alcohol oxidation activities of human Aldose reductase (hAR). Fluorescence emission measurements ...
Rice callus suspension culture inhibits growth of cell lines of multiple cancer types and induces apoptosis in lung cancer cell line
(BioMed Central Ltd., 2016)
Background: Cancer is one of the leading cause of mortality. Even though efficient drugs are being produced to treat cancer, conventional medicines are costly and have adverse effects. As a result, alternative treatments ...