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Novel potent inhibitors of Plasmodium vivax dihydrofolate reductase: An in silico antimalarial drug discovery
(Association of Pharmaceutical Teachers of India, 2018)
Objectives: In the present study, we targeted the dihydrofolate reductase enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolate which is required for the purines and pyrimidine synthesis. Malaria is one ...
miR-301, pleiotropic MicroRnA in Regulation of inflammatory Bowel Disease and ColitisAssociated Cancer
(Frontiers in Immunology, 2018)
Inflammatory bowel disease (IBD) is a chronic idiopathic, relapsing, and remitting immune disorders of gastrointestinal tract which consist of two forms, i.e., Crohn’s disease (affect the whole gastrointestinal tract) and ...
Nischarin regulates focal adhesion and Invadopodia formation in breast cancer cells
(BioMed Central Ltd., 2018)
Background: During metastasis, tumor cells move through the tracks of extracellular matrix (ECM). Focal adhesions (FAs) are the protein complexes that link the cell cytoskeleton to the ECM and their presence is necessary ...
Association of elevated levels of C-reactive protein with breast cancer, breast cancer subtypes, and poor outcome
(Mosby Inc., 2018)
Background and Purpose: Inflammation and caner are linked in a bidirectional manner. C-reactive protein (CRP) is an important inflammatory marker. The aim of the study was to test whether the inflammatory marker, CRP at ...
Bioactive carbohydrates
(Nova Science Publisher Inc., 2018)
Carbohydrates (also known as saccharides) are the chemical moieties composed of carbon, hydrogen and oxygen. Based upon their association they are known as monosaccharides, disaccharides, oligosaccharides and polysaccharides. ...
Bioactive peptides
(Nova Science Publisher Inc., 2018)
Peptides are small molecules composed of less than 20 amino acid residues. They are either derived from their parental polypeptide chains by enzymatic processes or even freely exist in natural sources. Bioactive peptides ...
Comparative metabolic profiling of vetiver (Chrysopogon zizanioides) and maize (Zea mays) under lead stress
(Elsevier Ltd, 2018)
Lead (Pb) contamination of residential soils in United States is attributed to use of Pb based paints prior to 1978 and their deterioration and accumulation in surface soils. Exposure to Pb due to ingestion and inhalation ...
Flavonoids: Synthesis and biological activities
(Nova Science Publisher Inc., 2018)
Flavonoid, the biggest class of secondary metabolite, are are found in vegetable, parsley, fruits, and wine. They are divided into distinct subgroups such as flavanols or catechins, flavones, flavanonols, flavanones, and ...
Inflammatory response of gliadin protein isolated from various wheat varieties on human intestinal cell line
(Academic Press, 2018)
Wheat protein contributes a significant part in human diet, apart from its well-known nutritional values, wheat gluten/gliadin proteins are also responsible for the many allergic/inflammatory diseases and chronic inflammation ...
Introduction to secondary metabolites
(Nova Science Publisher Inc., 2018)
Metabolic pathways in a microorganism, used for the production of energy, are known as primary metabolic pathway. The metabolic product or intermediary metabolites of primary metabolic pathway are used for the production ...