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Novel potent inhibitors of Plasmodium vivax dihydrofolate reductase: An in silico antimalarial drug discovery
(Association of Pharmaceutical Teachers of India, 2018)
Objectives: In the present study, we targeted the dihydrofolate reductase enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolate which is required for the purines and pyrimidine synthesis. Malaria is one ...
Proteomics provides insights into biological pathways altered by plant growth promoting bacteria and arbuscular mycorrhiza in sorghum grown in marginal soil
(Elsevier B.V., 2017)
Sorghum is an economically important crop, a model system for gene discovery and a biofuel source. Sorghum seedlings were subjected to three microbial treatments, plant growth promoting bacteria (B), arbuscular mycorrhizal ...
Oxidative Stress in Invertebrate Systems
(InTech, 2016)
Invertebrates have been valuable research models in the discovery of many scientific principles owing to the numerous advantages they provide. Throughout the life cycle, many of them thrive in pathogen-rich environments, ...
Oxidative Stress-Related MicroRNAs 6 as Diagnostic Markers: A Newer Insight in Diagnostics
(Springer, 2017)
Despite rapid strides in the medical and technological fields during the last four decades including the development of nucleic acid and protein-based biomarkers, the mortality still remains a burning problem because of ...
Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase
(American Society for Biochemistry and Molecular Biology Inc., 2017)
Nischarin (Nisch) is a key protein functioning as a molecular scaffold and thereby hosting interactions with several protein partners. To explore the physiological importance of Nisch, here we generated Nisch loss-of-function ...
Metabolomics, biomass and lignocellulosic total sugars analysis in foxtail millet (Setaria italica) inoculated with different combinations of plant growth promoting bacteria and mycorrhiza
(Communications in Plant Sciences, 2017)
Foxtail millet (Setaria italica) is the second most widely produced millet with potential as a biofuel source. Employment of plant growth promoting bacteria (PGPB) and mycorrhiza could serve as environment-friendly ...
Natural Compounds Are Smart Players in Context to Anticancer Potential of Receptor Tyrosine Kinases: An In Silico and In Vitro Advancement
(Springer, 2017)
Cancer is the ruling cause of mortality worldwide. Chemotherapeutic toxicity and drug resistance have provided impulsion for the formulation of new anticancer agents. Receptor tyrosine kinases (RTKs) are the most activated ...
Biological/Biosimilar Drugs: A New Hope for Better and Low Cost Treatment
(Juniper Publishers, 2016)
Biological and biosimilar drugs
Medicines that are derived from living cells/organisms are
known as biological medicines. They consist of of highly complex
molecular entities difficult to characterize. Certain degree ...
Recent advancement to target Breast Cancer and Cancer Stem Cells
(Open Access, 2017)
Breast cancer is the second most prominent reason of cancer death in women after lung cancer, and it accounts for 25.2% of all cancer in women [1]. In the US, approximately about one in eight women (12%) develop invasive ...