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Novel potent inhibitors of Plasmodium vivax dihydrofolate reductase: An in silico antimalarial drug discovery
(Association of Pharmaceutical Teachers of India, 2018)
Objectives: In the present study, we targeted the dihydrofolate reductase enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolate which is required for the purines and pyrimidine synthesis. Malaria is one ...
Geminin a multi task protein involved in cancer pathophysiology and developmental process: A review
(Elsevier B.V., 2016)
DNA replicates in a timely manner with each cell division. Multiple proteins and factors are involved in the initiation of DNA replication including a dynamic interaction between Cdc10-dependent transcript (Cdt1) and Geminin ...
Characterization of WY 14,643 and its complex with Aldose reductase
(Nature Publishing Group, 2016)
The peroxisome proliferator, WY 14,643 exhibits a pure non-competitive inhibition pattern in the aldehyde reduction and in alcohol oxidation activities of human Aldose reductase (hAR). Fluorescence emission measurements ...
Role of immune system in tumor progression and carcinogenesis
(Wiley-Liss Inc., 2018)
Tumor micro-environment has potential to customize the behavior of the immune cell according to their need. In immune-eliminating phase, immune cells eliminate transformed cells but after tumor establishment innate and ...