Department of Biochemistry and Microbial Sciences: Recent submissions
Now showing items 1-20 of 232
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Bioinformatics insights into CENP-T and CENP-W protein-protein interaction disruptive amino acid substitution in the CENP-T-W complex
(John Wiley and Sons Inc, 2023-11-09)Kinetochores are multi-protein assemblies present at the centromere of the human chromosome and play a crucial role in cellular mitosis. The CENP-T and CENP-W chains form a heterodimer, which is an integral part of the ... -
Immunodominant conserved moieties on spike protein of SARS-CoV-2 renders virulence factor for the design of epitope-based peptide vaccines
(Springer, 2023-11-23)The outbreak of novel SARS-CoV-2 virion has wreaked havoc with a high prevalence of respiratory illness and high transmission due to a vague understanding of the viral antigenicity, augmenting the dire challenge to public ... -
Combing of picogram level DNA equivalent to genomic DNA present in single human cell by self propelled droplet motion over a stable gradient surface
(Academic Press Inc., 2023-11-08)DNA combing is a powerful technique for studying replication profile, fork-directionality and fork velocity. At present, there is requirement of a methodology to comb DNA present in a single human cell for studying replication ... -
Genome-wide identification of NAC transcription factors in Avena sativa under salinity stress
(Elsevier B.V., 2023-10-29)Background: NAC (NAM, ATAF1/2, and CUC2) is one of the most prominent family of plant-specific transcription factors that play diverse roles in plant growth and development as well as in abiotic stress responses in plants. ... -
Synthesis, In silico mapping for anti-cancer proviso, hardness studies of D-gluconic acid monohydrate crystals for usage in electronic, mechanical and biological sectors
(Elsevier Ltd, 2023-10-17)D-Gluconic acid monohydrate - DGAMH crystals are grown in a period of 61 days by using the customary slow evaporation method with a, b and c as 8.4309, 5.409 and 10.4071 in � units; ? as 96.87�; monoclinic system, space ... -
Evolution of Nano-Biofertilizer as a Green Technology for Agriculture
(Multidisciplinary Digital Publishing Institute (MDPI), 2023-09-24)Agriculture has long been the cornerstone of human civilization, providing sustenance and livelihoods for millennia. However, as the global population continues to burgeon, agriculture faces mounting challenges. Soil ... -
Piper chaba, an Indian spice plant extract, inhibits cell cycle G1/S phase transition and induces intrinsic apoptotic pathway in luminal breast cancer cells
(John Wiley and Sons Ltd, 2023-09-15)Piper chaba (Piperaceae) is a medicinal spice plant that possesses several pharmacological activities. In the present study, we for the first time studied the effect of P. chaba extract on breast cancer cells. P. chaba ... -
Preparation, Characterization, and Biological Potential of Nanoemulsion from Rosmarinus officinalis L. Essential Oil
(Springer, 2023-10-02)Essential oil from Rosmarinus officinalis (also known as rosemary essential oil) is used as traditional medicine and used as therapeutic in medicine, food, and cosmetic sectors. However, this oil is highly unstable, volatile, ... -
SUMO and SUMOylation in Plants: Ignored Arsenal to Combat Abiotic Stress
(Springer, 2023-10-11)Plants being fixed in one place are exposed to various episodes of different abiotic stresses such as drought, salinity, cold, and heat. SUMOylation is one of the ignored arsenals that help plants to develop tolerance to ... -
Analysis of the Inhibitory Effect of hsa-miR-145-5p and hsa-miR-203a-5p on Imatinib-Resistant K562 Cells by GC/MS Metabolomics Method
(American Chemical Society, 2023-09-14)Imatinib (IM) resistance is considered to be a significant challenge in the management of chronic myeloid leukemia (CML). Previous studies have reported that hsa-miR-145-5p and hsa-miR-203a-5p can overcome IM resistance ... -
Antitubercular drugs: possible role of natural products acting as antituberculosis medication in overcoming drug resistance and drug-induced hepatotoxicity
(Springer Science and Business Media Deutschland GmbH, 2023-09-04)Mycobacterium tuberculosis (Mtb) is a pathogenic bacterium which causes tuberculosis (TB). TB control programmes are facing threats from drug resistance. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb ... -
MicroRNA based combinatorial therapy against TKIs resistant CML by inactivating the PI3K/Akt/mTOR pathway: a review
(Springer, 2023-09-15)Chronic myeloid leukemia (CML) is characterized by presence of Philadelphia chromosome, which harbors BCR-ABL oncogene responsible for encoding BCR-ABL oncoprotein. This oncoprotein interferes with cellular signaling ... -
Biochar as an Environment-Friendly Alternative for Multiple Applications
(Multidisciplinary Digital Publishing Institute (MDPI), 2023-09-07)The climate crisis and years of unsustainable agricultural practices have reduced soil fertility and crop yield. In addition, agricultural lands contribute more than 10% of greenhouse gases (GHGs). These concerns can be ... -
Nanoemulsions (O/W) prepared from essential oil extracted from Melaleuca alternifolia: synthesis, characterization, stability and evaluation of anticancerous, anti-oxidant, anti-inflammatory and antidiabetic activities
(Taylor and Francis Ltd., 2023-08-28)Essential oil from Melaleuca alternifolia (also known as Tea tree essential oil, TTO) is used as traditional medicine and used as therapeutic in medicine, food and cosmetic sectors. However, this oil is highly unstable, ... -
Role of Telomeres and Telomerase in Parkinson's Disease�A New Theranostics?
(John Wiley and Sons Inc, 2023-08-21)Parkinson's disease (PD) is a complex condition that is significantly influenced by oxidative stress and inflammation. It is also suggested that telomere shortening (TS) is regulated by oxidative stress which leads to ... -
Designing of neoepitopes based vaccine against breast cancer using integrated immuno and bioinformatics approach
(Taylor and Francis Ltd., 2023-08-16)Cancer is characterized by genetic instability due to accumulation of somatic mutations in the genes which generate neoepitopes (mutated epitopes) for targeting by Cytotoxic T lymphocytes (CTL). Breast cancer has a high ... -
A genome editing approach to enhance host resistance against plant-parasitic weeds
(Nova Science Publishers, Inc., 2023-08-14)Root-specific plant-parasitic weeds Phelipanche and Orobanche spp. (broomrape) induce potential damage to numerous crops and lead to heavy loss to the economy due to a reduction in total yield, especially in the Mediterranean, ... -
Leishmania donovani persistence and circulation causing cutaneous leishmaniasis in unusual-foci of Nepal
(Nature Research, 2023-07-29)Cutaneous leishmaniasis cases have increased dramatically in recent years in Nepal. The study offers molecular identification of the Leishmania species using 40 patient�s aspiration biopsy samples, targeting markers ... -
MicroRNAs Involved in Nutritional Regulation During Plant�Microbe Symbiotic and Pathogenic Interactions with Rice as a Model
(Springer, 2023-07-19)Plants are constantly challenged with numerous adverse environmental conditions, including biotic and abiotic stresses. Coordinated regulation of plant responses requires crosstalk between regulatory pathways initiated by ... -
Loss of miR-6844 alters stemness/self-renewal and cancer hallmark(s) markers through CD44-JAK2-STAT3 signaling axis in breast cancer stem-like cells
(John Wiley and Sons Inc, 2023-07-12)MicroRNAs regulate breast stemness and self-renewal properties in breast cancer cells at the molecular level. Recently we reported the clinical relevance and in vitro expression profile of novel miR-6844 in breast cancer ...