Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
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2016Author
Imamura, M.
Takahashi, A.
Yamauchi, T.
Hara, K.
Yasuda, K.
Grarup, N.
Zhao, W.
Wang, X.
Huerta-Chagoya, A.
Hu, C.
Moon, S.
Long, J.
Kwak, S.H.
Rasheed, A.
Saxena, R.
Ma, R.C.W.
Okada, Y.
Iwata, M.
Hosoe, J.
Shojima, N.
Iwasaki, M.
Fujita, H.
Suzuki, K.
Danesh, J.
J?rgensen, T.
J?rgensen, M.E.
Witte, D.R.
Brandslund, I.
Christensen, C.
Hansen, T.
Mercader, J.M.
Flannick, J.
Moreno-Mac?as, H.
Burtt, N.P.
Zhang, R.
Kim, Y.J.
Zheng, W.
Singh, J.R.
Tam, C.H.T.
H
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Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 ? 10-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities. ? 2016, Nature Publishing Group. All rights reserved.
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Nature Communications
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