Interleukin 1ß (+3954, -511 and -31) polymorphism in chronic periodontitis patients from North India
View/ Open
Date
2015Author
Amirisetty, Ramesh
Patel, Ritu Prabha
Das, Satrupa
Saraf, Jitendra
Jyothy, Akka
Munshi, Anjana
Metadata
Show full item recordAbstract
Objective. Several studies have implicated the role of interleukin-1 in various chronic diseases including periodontitis. The present study was carried out with an aim to evaluate the role of interleukin 1? polymorphisms, namely +3954C/T, -511C/T and -31T/C, in the development of chronic periodontitis. Materials and methods. Twenty-nine chronic periodontitis patients and 31 healthy controls of North Indian origin from Chhattisgarh were recruited for the study. The genotypes for the three variants were determined using the PCR-RFLP technique and the strength of association between genotypes and periodontitis was determined by odds ratio with 95% confidence interval (CI) and chi-square analysis. Results. Analysis for the +3954 allelic and genotypic frequencies of the polymorphism revealed a significant difference in the CT genotype between periodontitits patients and controls (p = 0.03). A significant difference was also observed in the allelic frequencies between the two groups (p = 0.02). For the -511 site, TT genotype revealed a significant association with the disease (p = 0.01). A significant association was also found following the co-dominant model (p = 0.007). However, the -31 polymorphism revealed no significant difference between patients and controls. Conclusions. In conclusion, the present study suggests a strong association of the TT genotype of -511 and CT genotype of +3954 variant of interleukin 1? with chronic periodontitis. However, the -31 variant did not show a significant association with the disease. ? Informa Healthcare.
Journal
Acta Odontologica Scandinavica
Collections
Related items
Showing items related by title, author, creator and subject.
-
Directory of human genetic services in India - 2007
Singh, J.R.; Singh, A.R.; Singh, A.R. (2010)[No abstract available] -
Shared and unique common genetic determinants between pediatric and adult celiac disease
Senapati, S.; Sood, A.; Midha, V.; Sood, N.; Sharma, S.; Kumar, L.; Thelma, B.K. (BioMed Central Ltd., 2016)Background: Based on age of presentation, celiac disease (CD) is categorised as pediatric CD and adult CD. It however remains unclear if these are genetically and/or phenotypically distinct disorders or just different ... -
Genetic determinants in ischaemic stroke subtypes: Seven year findings and a review
Munshi, Anjana; Das,Satrupa.; Kaul, Subhash (Elsevier, 2015)Stroke is a global health problem and a leading cause of disability worldwide. There have been numerable studies undertaking research on different aspects of ischaemic stroke employing various epidemiological, clinical and ...