| dc.contributor.author | Das, Satrupa | |
| dc.contributor.author | Kaul, & Subhash | |
| dc.contributor.author | Jyothy, Akka | |
| dc.contributor.author | Munshi, Anjana | |
| dc.date.accessioned | 2018-07-14T01:19:09Z | |
| dc.date.available | 2018-07-14T01:19:09Z | |
| dc.date.issued | 2017 | |
| dc.identifier.citation | Das, S., Kaul, S., Jyothy, A., & Munshi, A. (2017). Role of TLR4 (C1196T) and CD14 (C-260T) Polymorphisms in Development of Ischemic Stroke, Its Subtypes and Hemorrhagic Stroke. Journal of Molecular Neuroscience, 63(3-4), 300-307. doi: 10.1007/s12031-017-0979-9 | en_US |
| dc.identifier.issn | 8958696 | |
| dc.identifier.uri | http://kr.cup.edu.in/handle/32116/1459 | |
| dc.description.abstract | In the present study, we evaluated the association of TLR4 and CD14 polymorphisms, i.e. C1196T and C-260T, respectively, with ischemic stroke (n?=?700), its subtypes and hemorrhagic stroke (n?=?300) in a South Indian population from Telangana. The genotypes were determined using PCR?RFLP, and the strength of association between genotypes and stroke was determined by odds ratio with 95% confidence interval (CI) and chi-square analysis. The results revealed a lack of association for TLR4 variant with ischemic stroke and hemorrhagic stroke, although a significant association was observed with the subtypes extracranial large artery (p?=?0.008), other determined aetiology (p?=?0.03) and undetermined aetiology (p?=?0.01). Investigations on the variant of CD14 gene revealed negative association among ischemic stroke patients; however, a significant association was observed for hemorrhagic stroke following dominant and recessive genotypic model (p?=?0.05, p?=?0.02). Among ischemic stroke subtype, a significant association was observed with intracranial large artery, extracranial large artery, other determined aetiology and undetermined aetiology form of stroke (p?<?0.01). Further, analysis of the CD14 variant between the two major stroke types revealed a significant difference in genotype distribution following the co-dominant genotypic model (p?=?0.01). ? 2017, Springer Science+Business Media, LLC. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | Springer New York LLC | en_US |
| dc.subject | Cd14 Antigen | en_US |
| dc.subject | Toll Like Receptor 4 | en_US |
| dc.subject | Adult Brain Hemorrhage | en_US |
| dc.subject | Brain Ischemia | en_US |
| dc.subject | Controlled Study | en_US |
| dc.subject | Female | en_US |
| dc.subject | Gene Frequency | en_US |
| dc.subject | Genetic Polymorphism | en_US |
| dc.subject | Genotype | en_US |
| dc.subject | Human | en_US |
| dc.subject | Major Clinical Study | en_US |
| dc.subject | Male | en_US |
| dc.subject | Polymerase Chain Reaction | en_US |
| dc.subject | Restriction Fragment Length Polymorphism | en_US |
| dc.subject | Telangana | en_US |
| dc.title | Role of TLR4 (C1196T) and CD14 (C-260T) Polymorphisms in Development of Ischemic Stroke, Its Subtypes and Hemorrhagic Stroke | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | 10.1007/s12031-017-0979-9 | |
| dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12031-017-0979-9 | |
| dc.title.journal | Journal of Molecular Neuroscience | |
