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Investigation of combined genotoxic effect of pesticides on cancer cell lines
(Central University of Punjab, 2013)
The use of pesticides in agriculture sector is increasing widely to alleviate crop loss due to pests. To combat problem of pest, various types of pesticides are widely used, out of which insecticide are majorly used. In ...
Oxidative stress responses to sub-lethal dose of Cry toxin in the larvae of castor semilooper, Achaea janata
(Central University of Punjab, 2018)
Development of synthetic insecticides to reduce the level of infestation led to deleterious effects on environment and human health. This lead to the development of ecofriendly pest management alternatives including Bacillus ...
Effect of amyloid beta (25-35) peptide on mitochondrial respiratiory function in neuroral cells over expressing ape1
(Central University of Punjab, 2014)
Alzheimer's disease (AD) is an important public health problem which affects millions of people worldwide. The major pathological hallmarks associated with AD are the accumulation of amyloid beta (A?) in senile plaques and ...
Role of curcumin on monoamine oxidase(MAO) enzyme expression and activity against Amyloid Beta (A?)-induced oxidative stress in human glioblastoma U-87 MG cell.
(Central University of Punjab, 2018)
Glioblastoma (GBM) is the most common brain tumor in humans. The major factor responsible for its progression is oxidative stress. Oxidative stress leads to disruption of signaling pathways and damage to cells and tissues. ...
Assessment of Extract of Syzygium cumini Against Doxorubicin Induced Cardiotoxicity
(Central University of Punjab, 2018)
For the past four decades, doxorubicin (DOX) has been used to treat cancer, mainly solid tumours and haematological malignancies. However, clinical community is greatly concerned regarding the administration of this as DOX ...
Evaluation of amyloid beta (aβ)-induced Mitochondrial dysfunction: Neuroprotective role of Apurinic/apyrimidinic endonuclease (ape1) Via its interaction with cysteamine Dioxygenase (ado)
(Central University of Punjab, 2020)
Oxidative stress and damage to mitochondrial DNA during the aging process
can impair mitochondrial energy metabolism and ion homeostasis in neurons,
ultimately leading to neurodegeneration. Themain pathway for repairing ...
OXIDATIVE STRESS INDUCED CELL PROLIFERATION AND DNA REPAIR MECHANISMS IN GLIOBLASTOMA CELLS: ROLE OF ENPP2 AND APE1
(Central University of Punjab, 2018)
Glioblastoma Multiforme (GBM) is a grade IV, most frequent, and invasive devastating brain tumor with poor prognosis, even with the advancement of multimodal therapies, patients have survival period of less than 15 months. ...
ASSOCIATION OF OXIDATIVE STRESS WITH CYP1A2, CYP3A4, CYP2B6 AND PON1 GENETIC POLYMORPHISM IN AGRICULTURAL COMMUNITY OF BATHINDA
(Central University of Punjab, 2018)
The aim of present study is to evaluate the association of oxidative stress with CYP1A2, CYP3A4, CYP2B6 and PON1 genetic variation in the pesticide exposed (occupationally) population. The present study demonstrated that ...