Browsing Biochemistry and Microbial Sciences-Research Publications by Author "Verma, Malkhey"
Now showing items 1-11 of 11
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Aldose Reductase: a cause and a potential target for the treatment of diabetic complications
Thakur, Sapna; Gupta, Sonu Kumar; Ali, Villayat; Singh, Priyanka; Verma, Malkhey (Pharmaceutical Society of Korea, 2021-07-19)Diabetes mellitus, a disorder of metabolism, results in the elevation of glucose level in the blood. In this hyperglycaemic condition, aldose reductase overexpresses and leads to further complications of diabetes through ... -
Alterations in cellular metabolisms after Imatinib therapy: a review
Kumar, Veerandra; Singh, Priyanka; Gupta, Sonu Kumar; Ali, Villayat; Jyotirmayee; Verma, Malkhey (Springer, 2022-05-16)Chronic myeloid leukemia (CML) is characterized by the possession of the Philadelphia chromosome, which contains the Bcr-Abl oncogene that codes for the oncoprotein BCR-ABL. Through glucose metabolism, glycolysis, and the ... -
Analysis of the Inhibitory Effect of hsa-miR-145-5p and hsa-miR-203a-5p on Imatinib-Resistant K562 Cells by GC/MS Metabolomics Method
Singh, Priyanka; Yadav, Radheshyam; Verma, Malkhey; Chhabra, Ravindresh (American Chemical Society, 2023-09-14)Imatinib (IM) resistance is considered to be a significant challenge in the management of chronic myeloid leukemia (CML). Previous studies have reported that hsa-miR-145-5p and hsa-miR-203a-5p can overcome IM resistance ... -
Antileukemic Activity of hsa-miR-203a-5p by Limiting Glutathione Metabolism in Imatinib-Resistant K562 Cells
Singh, Priyanka; Yadav, Radheshyam; Verma, Malkhey; Chhabra, Ravindresh (MDPI, 2022-12-19)Imatinib has been the first and most successful tyrosine kinase inhibitor (TKI) for chronic myeloid leukemia (CML), but many patients develop resistance to it after a satisfactory response. Glutathione (GSH) metabolism is ... -
Combating TKI resistance in CML by inhibiting the PI3K/Akt/mTOR pathway in combination with TKIs: a review
Singh, Priyanka; Kumar, Veerandra; Gupta, Sonu Kumar; Kumari, Gudia; Verma, Malkhey (Springer, 2021-01-16)Chronic myeloid leukemia (CML), a myeloproliferative hematopoietic cancer, is caused by a genetic translocation between chromosomes 9 and 22. This translocation produces a small Philadelphia chromosome, which contains the ... -
Downregulation of Bcr-Abl oncogene in Chronic Myeloid Leukemia (CML) by microRNAs in case of Imatinib resistance
Singh, Priyanka; Gupta, Sonu Kumar; Ali, Vilayat; Verma, Malkhey (ASIAN PACIFIC JOURNAL OF HEALTH SCIENCES, 2018)The well-known myeloproliferative malignancy, chronic myeloid leukemia (CML), causes due to the formation of short and modified Philadelphia chromosome having the Bcr-Abl oncogene. Many therapeutic approaches have been made ... -
Maps for when the living gets tough : Maneuvering through a hostile energy landscape
Amondeel, Thierry D.G.; Rehman, Samrina; Zhang, Yanfei; Verma, Malkhey; Durre, Peter; Rehman, Matteo ina; Zhang, Yanfei; Verma, Malkhey (Elsevier, 2016)With genome sequencing of thousands of organisms, a scaffold has become available for data integration: molecular information can now be organized by attaching it to the genes and their gene-expression products. It is ... -
Metabolic flux analysis in plant metabolic network
Ali, Villayat; Singh, Priyanka; Gupta, Sonu; Vijaykumar; Mauley, Yogesh; Verma, Malkhey (2018) -
miR-145-5p and miR-203a-5p overcome imatinib resistance in myelogenous leukemic cells through metabolic reprogramming
Singh, Priyanka; Gupta, Sonu Kumar; Ali, Villayat; Chhabra, Ravindresh; Verma, Malkhey (National Institute of Science Communication and Policy Research, 2023-03-01)Imatinib is the most effective therapy for chronic myeloid leukemia (CML), but many patients eventually develop resistance to it after an initial satisfactory response. This study investigated the potential of three miRNAs ... -
Novel pharmacological approach for the prevention of multidrug resistance (MDR) in a human leukemia cell line
Gupta, Sonu Kumar; Singh, Priyanka; Chhabra, Ravindresh; Verma, Malkhey (Elsevier Ltd, 2021-06-11)Background: Drug resistance mechanisms are the regulatory factors associated with drug metabolism and drug transport to inward and outward of the target cells. Maybridge fragment (MBF) library is a collection of pharmacophore ... -
Transport and metabolism of tyrosine kinase inhibitors associated with chronic myeloid leukemia therapy: a review
Kumar, Veerandra; Singh, Priyanka; Gupta, Sonu Kumar; Ali, Villayat; Verma, Malkhey (Springer, 2022-02-07)Imatinib, nilotinib, dasatinib, bosutinib, ponatinib, and asciminib are FDA-approved tyrosine kinase inhibitors (TKIs) for chronic myeloid leukemia (CML), each of which has a specific pharmacological profile. Asciminib has ...