Browsing Biochemistry and Microbial Sciences-Research Publications by Submit Date
Now showing items 1-20 of 88
-
Plant tolerance to combined stress: An overview
(Springer India, 2017)The demand for food is predicted to increase by 70% in 2050 due to increasing world population. Efforts are being made to increase food production. However, abiotic and biotic stresses, which tend to reduce crop yield and ... -
Rice callus suspension culture inhibits growth of cell lines of multiple cancer types and induces apoptosis in lung cancer cell line
(BioMed Central Ltd., 2016)Background: Cancer is one of the leading cause of mortality. Even though efficient drugs are being produced to treat cancer, conventional medicines are costly and have adverse effects. As a result, alternative treatments ... -
Mycorrhiza and PGPB modulate maize biomass, nutrient uptake and metabolic pathways in maize grown in mining-impacted soil
(Elesevier, 2015)Abiotic stress factors including poor nutrient content and heavy metal contamination in soil, can limit plant growth and productivity. The main goal of our study was to evaluate element uptake, biomass and metabolic responses ... -
Mycorrhiza and heavy metal resistant bacteria enhance growth, nutrient uptake and alter metabolic profile of sorghum grown in marginal soil
(Elsevier Ltd, 2016)The main challenge for plants growing in nutrient poor, contaminated soil is biomass reduction, nutrient deficiency and presence of heavy metals. Our aim is to overcome these challenges using different microbial combinations ... -
Characterization of WY 14,643 and its complex with Aldose reductase
(Nature Publishing Group, 2016)The peroxisome proliferator, WY 14,643 exhibits a pure non-competitive inhibition pattern in the aldehyde reduction and in alcohol oxidation activities of human Aldose reductase (hAR). Fluorescence emission measurements ... -
Maps for when the living gets tough : Maneuvering through a hostile energy landscape
(Elsevier, 2016)With genome sequencing of thousands of organisms, a scaffold has become available for data integration: molecular information can now be organized by attaching it to the genes and their gene-expression products. It is ... -
Proteomics provides insights into biological pathways altered by plant growth promoting bacteria and arbuscular mycorrhiza in sorghum grown in marginal soil
(Elsevier B.V., 2017)Sorghum is an economically important crop, a model system for gene discovery and a biofuel source. Sorghum seedlings were subjected to three microbial treatments, plant growth promoting bacteria (B), arbuscular mycorrhizal ... -
Withania somnifera chemotype NMITLI 101R significantly increases the efficacy of antileishmanial drugs by generating strong IFN-γ and IL-12 mediated immune responses in Leishmania donovani infected hamsters
(Elsevier, 2017)Background Withania somnifera (L.) Dunal (Solanaceae), commonly known as Ashwagandha, is one of the most important medicinal plant in the traditional Indian medical systems. Pharmacological studies have established that ... -
Book Review: Gastrointestinal Physiology and Diseases Methods and Protocols
(Frontiers in Cellular and Infection Microbiology, 2017)The gastrointestinal tract is one of the largest immunological organs and plays a pivotal role in maintaining normal homeostasis in the body. The statement made by Hippocrates more than 2,000 years ago “all disease begins ... -
Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase
(American Society for Biochemistry and Molecular Biology Inc., 2017)Nischarin (Nisch) is a key protein functioning as a molecular scaffold and thereby hosting interactions with several protein partners. To explore the physiological importance of Nisch, here we generated Nisch loss-of-function ... -
D Allele Frequency in Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme (ACE) Gene is Associated with Development of Breast Cancer Risk in Indian Women
(Bentham Science, 2016)Aims: Breast cancer is the second most common cancer in the world and, by far, the most frequent cancer among women. Scientific literature has hypothesized the association of ACE I/D polymorphism with breast cancer for ... -
Geminin as an Emerging Anticancer Drug Target
(Juniper Publishers, 2016)For normal cell division, one time replication origin firing is mandatory. The mutual interaction and levels of Cdt1 and geminin (GMNN) proteins are known to be involved in this regulatory mechanism. Imbalance between these ... -
Novel potent inhibitors of Plasmodium vivax dihydrofolate reductase: An in silico antimalarial drug discovery
(Association of Pharmaceutical Teachers of India, 2018)Objectives: In the present study, we targeted the dihydrofolate reductase enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolate which is required for the purines and pyrimidine synthesis. Malaria is one ... -
Association of MTHFR (C677T) Gene Polymorphism With Breast Cancer in North India
(Sage, 2016)Background Breast cancer is one of the most common malignancies in women and is associated with a variety of risk factors. The functional single-nucleotide polymorphism (SNP) C677T in the gene encoding 5,10-methylenetet ... -
Inter Conversion of Somatic and Cancer Stem Cell: From Discovery to New Paradigm in Cancer Therapy
(OMICS International, 2017)Organ is composed of special type of tissue and cells. Deficits in functionality and number of particular cells lead to the development of various type of human disease such as diabetes, neurological disease, cardiovascular, ... -
Novel Wnt and Notch Signaling Natural Inhibitors as Double Edged Sword Against Cancer War: An approach Towards Computer Based Drug Design
(Juniper Publishers, 2016)Cancer is a group of disease characterized by the uncontrolled growth and spread of abnormal cells which may lead to death. According to a report by GLOBOCAN the number of new cancer cases would increase to 19.3 million ... -
Biological/Biosimilar Drugs: A New Hope for Better and Low Cost Treatment
(Juniper Publishers, 2016)Biological and biosimilar drugs Medicines that are derived from living cells/organisms are known as biological medicines. They consist of of highly complex molecular entities difficult to characterize. Certain degree ... -
Recent advancement to target Breast Cancer and Cancer Stem Cells
(Open Access, 2017)Breast cancer is the second most prominent reason of cancer death in women after lung cancer, and it accounts for 25.2% of all cancer in women [1]. In the US, approximately about one in eight women (12%) develop invasive ... -
Oxidative Stress in Invertebrate Systems
(InTech, 2016)Invertebrates have been valuable research models in the discovery of many scientific principles owing to the numerous advantages they provide. Throughout the life cycle, many of them thrive in pathogen-rich environments, ...
