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Natural Compounds Are Smart Players in Context to Anticancer Potential of Receptor Tyrosine Kinases: An In Silico and In Vitro Advancement
(Springer, 2017)
Cancer is the ruling cause of mortality worldwide. Chemotherapeutic toxicity and drug resistance have provided impulsion for the formulation of new anticancer agents. Receptor tyrosine kinases (RTKs) are the most activated ...
Biological/Biosimilar Drugs: A New Hope for Better and Low Cost Treatment
(Juniper Publishers, 2016)
Biological and biosimilar drugs
Medicines that are derived from living cells/organisms are
known as biological medicines. They consist of of highly complex
molecular entities difficult to characterize. Certain degree ...
Geminin as an Emerging Anticancer Drug Target
(Juniper Publishers, 2016)
For normal cell division, one time replication origin firing is
mandatory. The mutual interaction and levels of Cdt1 and geminin
(GMNN) proteins are known to be involved in this regulatory
mechanism. Imbalance between these ...
Oxidative Stress-Related MicroRNAs 6 as Diagnostic Markers: A Newer Insight in Diagnostics
(Springer, 2017)
Despite rapid strides in the medical and technological fields during the last four decades including the development of nucleic acid and protein-based biomarkers, the mortality still remains a burning problem because of ...
Novel Wnt and Notch Signaling Natural Inhibitors as Double Edged Sword Against Cancer War: An approach Towards Computer Based Drug Design
(Juniper Publishers, 2016)
Cancer is a group of disease characterized by the uncontrolled growth and spread of abnormal cells which may lead to death. According to
a report by GLOBOCAN the number of new cancer cases would increase to 19.3 million ...
Inter Conversion of Somatic and Cancer Stem Cell: From Discovery to New Paradigm in Cancer Therapy
(OMICS International, 2017)
Organ is composed of special type of tissue and cells. Deficits in
functionality and number of particular cells lead to the development of
various type of human disease such as diabetes, neurological disease,
cardiovascular, ...
D Allele Frequency in Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme (ACE) Gene is Associated with Development of Breast Cancer Risk in Indian Women
(Bentham Science, 2016)
Aims: Breast cancer is the second most common cancer in the world and, by far, the most frequent cancer among women. Scientific literature has hypothesized the association of ACE I/D polymorphism with breast cancer for ...
Polydopamine films change their physicochemical and antimicrobial properties with a change in reaction conditions
(Royal Society of Chemistry, 2018)
The morphology and physicochemical properties of polydopamine are not totally inherent and undergo changes with differing reaction conditions like the choice of solvent used for polymerization. The polymerisation of dopamine ...
Recent advancement to target Breast Cancer and Cancer Stem Cells
(Open Access, 2017)
Breast cancer is the second most prominent reason of cancer death in women after lung cancer, and it accounts for 25.2% of all cancer in women [1]. In the US, approximately about one in eight women (12%) develop invasive ...
Geminin a multi task protein involved in cancer pathophysiology and developmental process: A review
(Elsevier B.V., 2016)
DNA replicates in a timely manner with each cell division. Multiple proteins and factors are involved in the initiation of DNA replication including a dynamic interaction between Cdc10-dependent transcript (Cdt1) and Geminin ...