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In silico identification of natural anticancer product and their efficacy in breast cancer cells and cancer stem like cells
(Central University of Punjab, 2020)
Breast cancer is the most commonly diagnosed lethal cancer in women worldwide.
Notch signaling pathway is directly linked to breast cancer recurrence and
aggressiveness. Natural remedies are becoming a prime choice to ...
Phytochemical ginkgolide b protects cultured neuroblastoma SH-SY5Y cells against a?(25-35) induced oxidative stress responses by maintaining the mitochondrial integrity
(Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma, 2020)
Alzheimer�s disease is associated with oxidative stress induced by accumulation of A? peptide, by disrupting the mitochondrial function. In this study, the oxidative stress responses induced by A?(25-35) and protective ...
Drug-metabolizing enzymes: role in drug resistance in cancer
(Springer, 2020)
Although continuous researches are going on for the discovery of new chemotherapeutic agents, resistance to these anticancer agents has made it really difficult to reach the fruitful results. There are many causes for this ...
Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies
(Taylor and Francis Ltd., 2020)
Coronaviruses are contagious pathogens primarily responsible for respiratory and intestinal infections. Research efforts to develop antiviral agents against coronavirus demonstrated the main protease (Mpro) protein may ...
Primary metabolites from overproducing microbial system using sustainable substrates
(Wiley-Blackwell Publishing Ltd, 2020)
Primary (or secondary) metabolites are produced by animals, plants, or microbial cell systems either intracellularly or extracellularly. Production capabilities of microbial cell systems for many types of primary metabolites ...
Circulating microRNA-590-5p functions as a liquid biopsy marker in non-small cell lung cancer
(Blackwell Publishing Ltd, 2020)
Despite the availability of various diagnostic procedures, a tissue biopsy is still indispensable for the routine diagnosis of lung cancer. However, inaccurate diagnoses can occur, leading to inefficient cancer management. ...
MicroRNA Targeting Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Cancer
(Mary Ann Liebert Inc., 2020)
Significance: Reactive oxygen species (ROS) production occurs primarily in the mitochondria as a by-product of cellular metabolism. ROS are also produced by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases in ...
Brown gold of marginal soil: Plant growth promoting bacteria to overcome plant abiotic stress for agriculture, biofuels and carbon sequestration
(Elsevier B.V., 2020)
Marginal land is defined as land with poor soil characteristics and low crop productivity with no potential for profit. Poor soil quality due to the presence of xenobiotics or climate change is of great concern. Sustainable ...
Emerging role of ZBTB7A as an oncogenic driver and transcriptional repressor
(Elsevier, 2020)
ZBTB7A is a member of the POK family of transcription factors that possesses a POZ-domain at the N-terminus and Krüppel-like zinc-finger at the c-terminus. ZBTB7A was initially isolated as a protein that binds to the inducer ...
Anti-cancer drug doxorubicin induced cardiotoxicity: Understanding the mechanisms involved in ros generation resulting in mitochondrial dysfunction
(Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma, 2020)
Doxorubicin (DOX), despite being an effective anti-cancer drug has offsite targets that affect the vital organs such as heart, brain and kidney. DOX-induced cardiotoxicity is reported as a multi-factorial process that ...