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Study the effect of phytochemicals phenethyl isothiocyanate (PEITC) and Quercetin on mitochondrial biogenesis in cancer and normal cell lines
(Central University of Punjab, 2018)
Phytochemicals are plant-derived chemicals generally are biologically active compounds and mediate positive health benefits by targeting genes or metabolic pathways of a cell. The phytochemicals examined can be classified ...
Generation of Rho-0 Cells using MDA-MB-231 Cell Line and Measurement of Drug Cytotoxicity
(Central University of Punjab, 2018)
The ATP generation via Oxidative phosphorylation (OXPHOS) system located in the inner membrane of mitochondria, is regulated by the coordinated interaction between nucleus and mitochondria. In the same context, ...
Imidazole based compunds: Synethesis and in vitro anticancer screening
(Central University of Punjab, 2013)
Imidazole is an important five-membered aromatic heterocycle widely present in natural products and synthetic molecules. The unique structural feature of imidazole ring with desirable electron rich characteristic is ...
Potential Mitochondrial-Specific Function Of piRNAs
(Central University of Punjab, 2018)
Piwi-interacting RNAs (piRNAs) are (26-31 nt) small noncoding RNAs processed from their longer precursor transcripts with the help of Piwi proteins. There are more than 30,000 piRNA genes present in the human genome which ...
Antiproliferative Activity of Chloroform and Methanol Extracts of Piper attenuatum (Buch-Ham)
(Central University of Punjab, 2018)
Indian traditional medicinal plant Piper attenuatum (Buch-Ham) has been investigated for its antiproliferative activity. Dried powder of fruits of Piper attenuatum (Buch-Ham) was subjected to maceration to prepare various ...
Synthesis And Antiproliferative Activity Of Pyrazole-Based Heterocycles
(Central University of Punjab, 2018)
Among the various heterocyclic compounds pyrazole and its derivatives have occupied wide range of biological and pharmacological activities. These were observed for their modes of function in the inhibition of topoisomerase ...
Synthesis, Characterization and Biological Evaluation of 5-(2- Nitrophenyl)-1H-Pyrazole Derivatives as Putative Antiproliferative Agents
(Central University of Punjab, 2018)
Pyrazoles are known to exhibit various biological activities like antibacterial, antiprotozoal, anticonvulsant, analgesic, anti-inflammatory, antiviral and antiproliferative. An attempt has been made to synthesize substituted ...
Synthesis and In Silico Studies Of Quinazolinone Derivatives As PARP-1 INHIBITORS
(Central University of Punjab, 2018)
Cancer is one of the leading diseases responsible for high mortality rates worldwide. It develops when normal cells begin to grow out of control in particular part of the body. Cancer is a leading cause of death worldwide, ...
Impact of mitochondrial transplantation on cancer cells
(Central University of Punjab, 2014)
Mitochondria, the powerhouse of the cell, are small granular or filamentous bodies associated significantly with cellular respiration and are the main sources of energy, due to which they are present in maximum number in ...