Browsing Zoology-Research Publications by Title
Now showing items 29-48 of 173
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Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment
(Neoplasia Press, Inc., 2020)Based on epidemiological data provided by the World Health Organization (2018), cancer is the second most prevalent cause of death worldwide. Several factors are thought to contribute to the high mortality rate in cancer ... -
CHAPTER 9: Nanomaterial-Blood Interactions: A Biomedical Perspective
(Royal Society of Chemistry, 2019)Within the short span of a decade, nanotechnology has gained tremendous recognition in diagnostic and therapeutic applications owing to its unique physiochemical properties. Whenever nanomaterials (NMs) are intravenously ... -
Circulating long non-coding RNA EWSAT1 acts as a liquid biopsy marker for esophageal squamous cell carcinoma: A pilot study
(KeAi Communications Co., 2023-10-28)The widespread public health problem of esophageal squamous cell carcinoma (ESCC) is the cause of an increasing number of deaths each year due to delayed diagnosis. Therefore, we require specific and sensitive new biomarkers ... -
Circulating Long Non-Coding RNAs LINC00324 and LOC100507053 as Potential Liquid Biopsy Markers for Esophageal Squamous Cell Carcinoma: A Pilot Study
(Frontiers Media S.A., 2022-02-14)Background: Despite the availability of advanced technology to detect and treat esophageal squamous cell carcinoma (ESCC), the 5-year survival rate of ESCC patients is still meager. Recently, long non-coding RNAs (lncRNAs) ... -
Circulating microRNA-590-5p functions as a liquid biopsy marker in non-small cell lung cancer
(Blackwell Publishing Ltd, 2020)Despite the availability of various diagnostic procedures, a tissue biopsy is still indispensable for the routine diagnosis of lung cancer. However, inaccurate diagnoses can occur, leading to inefficient cancer management. ... -
Circulating miR-320a Acts as a Tumor Suppressor and Prognostic Factor in Non-small Cell Lung Cancer
(Frontiers Media S.A., 2021-03-23)Dysregulated expression profiles of microRNAs (miRNAs) have been observed in several types of cancer, including non-small cell lung cancer (NSCLC); however, the diagnostic and prognostic potential of circulating miRNAs in ... -
Clinical potential of long non-coding RNA LINC01133 as a promising biomarker and therapeutic target in cancers
(Newlands Press Ltd, 2022-02-23)Recently, long intergenic non-protein coding RNA 01133 (LINC01133) was identified as a novel transcript in cancers. It modulates various hallmarks of cancers and acts as oncogenic in some cancers while tumor-suppressive ... -
Cloning and characterization of a riboflavin-binding hexamerin from the larval fat body of a lepidopteran stored grain pest, Corcyra cephalonica
(Elsevier Inc., 2016)In the present study, a riboflavin-binding hexamerin (RbHex) was cloned and characterized from the larval fat body of Corcyra cephalonica. The complete cDNA (2121 bp) encodes a 706-amino acid protein with a molecular mass ... -
Cloning, characterization and transmission blocking potential of midgut carboxypeptidase A in Anopheles stephensi
(Elsevier B.V., 2017)Transmission-blocking vaccines (TBV) interrupt malaria parasite transmission and hence form an important component for malaria eradication. Mosquito midgut exopeptidases such as aminopeptidase N & carboxypeptidase B have ... -
Cloning, expression and in vitro validation of chimeric multi epitope vaccine candidate against visceral leishmaniasis infection
(Elsevier Inc., 2023-04-11)Visceral Leishmaniasis or Kala-Azar is one of the most severe and deadly neglected tropical disease caused by the Leishmania parasite. A few number of vaccines are going through different phases in clinical trial but failing ... -
A comprehensive review on the decabromodiphenyl ether (BDE-209)-induced male reproductive toxicity: Evidences from rodent studies
(Elsevier B.V., 2023-08-02)Polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardants (BFRs), are employed in various manufactured products to prevent fires, slow down their spread and reduce the resulting damages. Decabromodiphenyl ... -
Concurrent Assessment of Oxidative Stress and MT-ATP6 Gene Profiling to Facilitate Diagnosis of Autism Spectrum Disorder (ASD) in Tamil Nadu Population
(Springer, 2023-03-27)Autism spectrum disorder (ASD) is a neurodevelopmental disability that causes social impairment, debilitated verbal or nonverbal conversation, and restricted/repeated behavior. Recent research reveals that mitochondrial ... -
Connecting the Link between Oxidative Stress, Dietary Antioxidants and Hypertension
(CRC Press, 2023-06-12)Cardiovascular disorders such as hypertension, coronary heart disease (CHD), cerebrovascular disease, etc. accounts for millions of deaths per year and among these, hypertension (i.e. increased blood pressure) acts as a ... -
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes
(2013)Non-coding apurinic/apyrimidinic (AP) sites in DNA form spontaneously and as DNA base excision repair intermediates are the most common toxic and mutagenic in vivo DNA lesion. For repair,APsites must be processed by 5' AP ... -
The creation of selenium nanoparticles decorated with troxerutin and their ability to adapt to the tumour microenvironment have therapeutic implications for triple-negative breast cancer
(Royal Society of Chemistry, 2023-02-09)Despite advancements in treatment, managing aggressive types of breast cancer, particularly Triple Negative Breast Cancer (TNBC), remains a daunting task. Newer chemotherapeutics enhance the multidrug resistance in cancer ... -
Crosstalk between platelet and bacteria: A therapeutic prospect
(Bentham Science Publishers, 2019)Platelets are typically recognized for their roles in the maintenance of hemostasis and vascular wall repair to reduce blood loss. Beyond hemostasis, platelets also play a critical role in pathophysiological conditions ... -
Curcumin revitalizes Amyloid beta (25–35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2
(Springer, 2017)Amyloid beta (Aβ) peptide deposition is the primary cause of neurodegeneration in Alzheimer’s disease (AD) pathogenesis. Several reports point towards the role of pesticides in the AD pathogenesis, especially organophosphate ... -
Decabromodiphenyl ether (BDE-209) exposure to lactating mice perturbs steroidogenesis and spermatogenesis in adult male offspring
(Academic Press, 2020-12-29)Decabromodiphenyl ether (BDE-209) is widely used as a flame retardant in many products like electronic equipments, plastics, furniture and textiles. BDE-209, a thyroid hormones (THs)-disrupting chemical, affects male ... -
A deeper understanding about the role of uranium toxicity in neurodegeneration
(Academic Press Inc., 2023-06-15)Natural deposits and human-caused releases of uranium have led to its contamination in the nature. Toxic environmental contaminants such as uranium that harm cerebral processes specifically target the brain. Numerous ...