Browsing Zoology-Research Publications by Title
Now showing items 80-99 of 173
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Identification of novel indole based heterocycles as selective estrogen receptor modulator.
(Elsevier, 2018)In the present study, we have designed and synthesized indole derivatives by coalescing the indole nucleus with chromene carbonitrile and dihydropyridine nucleus. Two compounds 5c and 6d were selected from series I and II ... -
The imminent role of microRNAs in salivary adenoid cystic carcinoma
(Neoplasia Press, Inc., 2022-11-04)Unfortunately, despite the severe problem associated with salivary adenoid cystic carcinoma (SACC), it has not been studied in detail yet. Therefore, the time has come to understand the oncogenic cause of SACC and find the ... -
Impact of noncoding RNAs on cancer directed immune therapies: Now then and forever
(John Wiley and Sons Inc, 2022-04-30)Accumulating evidence demonstrates that the host genome's epigenetic modifications are essential for living organisms to adapt to extreme conditions. DNA methylation, covalent modifications of histone and interassociation ... -
The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review
(MDPI, 2023-01-16)As a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women�s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, ... -
Implications of cancer stem cells in diabetes and pancreatic cancer
(Elsevier Inc., 2022-11-19)This review provides a detailed study of pancreatic cancer (PC) and the implication of different types of cancers concerning diabetes. The combination of anti-diabetic drugs with other anti-cancer drugs and phytochemicals ... -
Implicative role of cytokines in neuroinflammation mediated AD and associated signaling pathways: Current progress in molecular signaling and therapeutics
(Elsevier Ireland Ltd, 2023-10-30)Alzheimer's Disease (AD) is one of the most devastating age-related disorder causing significant social and economic burden worldwide. It affects the cognitive and social behavior of individuals and characterized by ... -
In silico evaluation of natural compounds to confirm their anti-DNA gyrase activity
(Springer, 2023-06-03)The slow clearance of bacteria owing to drug resistance to the currently available antibiotics has been a global public health issue. The development of antibiotic resistance in Staphylococcus aureus has become prevalent ... -
An in vitro study ascertaining the role of H2O2 and glucose oxidase in modulation of antioxidant potential and cancer cell survival mechanisms in glioblastoma U-87 MG cells
(Springer New York LLC, 2017)Glial cells protect themselves from the elevated reactive oxygen species (ROS) via developing unusual mechanisms to maintain the genomic stability, and reprogramming of the cellular antioxidant system to cope with the ... -
The incidence of male breast cancer: from fiction to reality - correspondence
(NLM (Medline), 2023-05-24)[No abstract available] -
Indian Herbs and their Therapeutic Potential against Alzheimer’s Disease and other Neurological Disorders
(Wiley, 2017)Many present-day diseases are caused by disruption of the delicate balance between the reactive oxygen/nitrogen species (ROS/RNS) produced by oxidants and their scavenging by the antioxidants in the body. Chief among them ... -
An Insight Into Systemic Immune Response in Leishmania donovani Mediated Atypical Cutaneous Leishmaniasis in the New Endemic State of Himachal Pradesh, India
(Frontiers Media S.A., 2022-01-04)Leishmaniasis continues to afflict known and newer endemic sites despite global efforts towards its control and elimination. In this regard, the emergence of newer endemic sites with unusual disease formats is recognized ... -
Insights into the Scenario of SARS-CoV-2 Infection in Male Reproductive Toxicity
(MDPI, 2023-02-23)COVID-19 has become a significant public health concern that has catastrophic consequences for society. Some preliminary evidence suggests that the male reproductive system may be an infection target for SARS-CoV-2. ... -
An intraspecies Leishmania donovani hybrid from the Indian subcontinent is associated with an atypical phenotype of cutaneous disease
(Elsevier Inc., 2022-01-22)Leishmaniasis is a neglected tropical disease endemic in over 90 countries. The disease has two main pathologies; cutaneous leishmaniasis (CL) that generally self-heals, and visceral leishmaniasis (VL) that is fatal if ... -
Investigating regulatory signatures of human autophagy related gene 5 (ATG5) through functional in silico analysis
(Elsevier B.V., 2016)Autophagy is an essential, homeostatic process which removes damaged cellular proteins and organelles for cellular renewal. ATG5, a part of E3 ubiquitin ligase-like complex (Atg12-Atg5/Atg16L1), is a key regulator involved ... -
Larval mid-gut responses to sub-lethal dose of cry toxin in lepidopteran pest Achaea janata
(Frontiers Media S.A., 2017)The lack of homogeneity in field application of Bacillus thuringiensis formulation often results in ingestion of sub-lethal doses of the biopesticide by a fraction of pest population and there by promotes the toxin tolerance ... -
LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway
(Elsevier Inc., 2022-12-06)Long non-coding RNAs have been demonstrated to promote proliferation and metastasis via regulating the miRNA/mRNA regulatory axis in various malignancies. Based on our preliminary study, we investigated the mechanism of ... -
LncRNA ZFAS1 inhibits triple-negative breast cancer by targeting STAT3
(Elsevier B.V., 2021-01-11)Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with fewer treatment options than other types of invasive breast cancer due to the loss of the estrogen, progesterone receptors and low ... -
Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development
(Elsevier Inc., 2023-02-24)The orexins (OXs) were first reported in hypothalamus of rat, and they play an important role in diverse physiological actions. The OXs consist of orexin A (OXA) and orexin B (OXB) peptides and their actions are mediated ... -
Low dose radiation primed iNOS + M1macrophages modulate angiogenic programming of tumor derived endothelium.
(PLOS, 2018)Solid tumors are covered by stroma, which is hypoxic in nature and composed of various non‐malignant components such as endothelial cells, fibroblasts, and pericytes that support tumor growth. Tumor stroma represents a ...