Browsing Zoology-Research Publications by Title
Now showing items 140-159 of 173
-
Quantification and optimization of clot retraction in washed human platelets by Sonoclot coagulation analysis
(John Wiley and Sons Inc, 2021-10-07)Introduction: Clot retraction is a pivotal process for haemostasis, where platelets develop a contractile force in fibrin meshwork and lead to the increased rigidity of clot. The pathophysiological alteration in contractile ... -
Rapid Arc-SBRT: Non-Invasive Immune Adjuvant for Advanced Stage Non-Small Cell Lung Carcinoma
(Bentham Science Publishers, 2021-03-23)In conjunction with radio-chemotherapy, pulmonary resection is recommended for early-stage non-small-cell lung carcinoma but not for advanced-stage NSCLC patients having high-grade metastatic lesions. In these cases, the ... -
Recent advances in understanding brain cancer metabolomics: a review
(Springer, 2023-07-10)Regardless of the significant progress made in surgical techniques and adjuvant therapies, brain tumors are a major contributor to cancer-related morbidity and mortality in both pediatric and adult populations. Gliomas ... -
Recent developments on the structure–activity relationship studies of MAO inhibitors and their role in different neurological disorders
(Royal Society of Chemistry, 2016)Monoamine oxidase (MAO) enzyme catalyzes the oxidative deamination of xenobiotic and endogenous amines including many neurotransmitters. The MAO enzyme exists in two isoforms; MAO-A and MAO-B and these isoforms display ... -
Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation
(Impact Journals, 2016)Mammalian apurinic/apyrimidinic (AP) endonuclease 1 (APE1), a ubiquitous and multifunctional protein, plays an essential role in the repair of both endogenous and drug-induced DNA damages in the genome. Unlike its E.coli ... -
The regulatory roles of long non-coding RNAs in the development of chemoresistance in breast cancer
(Impact Journals LLC, 2017)Chemoresistance is one of the major hurdles in the treatment of breast cancer, which limits the effect of both targeted and conventional therapies in clinical settings. Therefore, understanding the mechanisms underpinning ... -
Rest of the carpenter ant�Camponotus compressus�undergoes a drastic change after mating
(Springer Science and Business Media Deutschland GmbH, 2023-01-04)Studies on many species have suggested that animals across the taxa remain behaviourally motionless for a significant part of their active phase. It is true of social insects such as ants, which constitute a considerable ... -
Retinal Changes in Parkinson�s Disease: A Non-invasive Biomarker for Early Diagnosis
(Springer, 2023-10-13)Parkinson�s disease (PD) is caused due to degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) which leads to the depletion of dopamine in the body. The lack of dopamine is mainly due to ... -
A review on protein–protein interaction network of APE1/Ref-1 and its associated biological functions
(Wiley, 2015)Apurinic/apyrimidinic endonuclease 1 (APE1) is a classic example of functionally variable protein. Besides its well-known role in (i) DNA repair of oxidative base damage, APE1 also plays a critical role in (ii) redox ... -
RNA-Seq analysis and de novo transcriptome assembly of Cry toxin susceptible and tolerant Achaea janata larvae
(NLM (Medline), 2019)Larvae of most lepidopteran insect species are known to be voracious feeders and important agricultural pests throughout the world. Achaea janata larvae cause serious damage to Ricinus communis (Castor) in India resulting ... -
Role of Metabolism and Metabolic Pathways in Prostate Cancer
(MDPI, 2023-01-26)Prostate cancer (PCa) is the common cause of death in men. The pathophysiological factors contributing to PCa are not well known. PCa cells gain a protective mechanism via abnormal lipid signaling and metabolism. PCa cells ... -
Role of Neurons and Glia Cells in Wound Healing as a Novel Perspective Considering Platelet as a Conventional Player
(Springer, 2021-10-11)Wound healing is a complex physiological process in which the damaged or injured tissue is replaced or regenerated by new cells or existing cells respectively in their synthesized and secreted matrices. Several cells ... -
Role of platelet in Parkinson's disease: Insights into pathophysiology & theranostic solutions
(Elsevier Ireland Ltd, 2022-07-04)Parkinson's disease (PD) is the second-most-common neurodegenerative disease characterized by motor and non-motor dysfunctions, which currently affects about 10 million people worldwide. Gradual death and progressive loss ... -
Role of reactive oxygen species in cancer progression: Molecular mechanisms and recent advancements
(MDPI AG, 2019)Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production in normal cells is controlled by the appropriate regulation between the silver lining of low and high ROS concentration ... -
Role of sphingosine-1-phosphate in mast cell functions and asthma and its regulation by non-coding RNA
(Frontiers Media S.A., 2017)Sphingolipid metabolites are emerging as important signaling molecules in allergic diseases specifically asthma. One of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), is involved in cell differentiation, ... -
Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
(Impact Journals LLC, 2016)Ionizing radiation (IR) induces highly cytotoxic double-strand breaks (DSBs) and also clustered oxidized bases in mammalian genomes. Base excision repair (BER) of bi-stranded oxidized bases could generate additional DSBs ... -
A short review on the implications of base excision repair pathway for neurons: Relevance to neurodegenerative diseases
(Elsevier, 2014)Oxidative DNA damage results from the attack by reactive oxygen and nitrogen species (ROS/RNS) on human genome. This includes base modifications such as oxidized bases, abasic (AP) sites, and single-strand breaks (SSBs), ... -
A short review: Doxorubicin and its effect on cardiac proteins
(Wiley-Liss Inc., 2020-12-26)Doxorubicin (DOX) is a boon for cancer-suffering patients. However, the undesirable effect�on health on vital organs, especially the heart, is a�limiting factor, resulting in an increased number of patients with cardiac ... -
Significant structural change in human c-Myc promoter G-quadruplex upon peptide binding in potassium
(Royal Society of Chemistry, 2022-03-08)We selected the G-quadruplex motif located in the nuclease-hypersensitive elements (NHE) III1 region of the c-Myc promoter and for the first time performed its interaction studies with a designed peptide (QW10). Our CD ... -
SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer
(Frontiers Media S.A., 2019)Limitations in current diagnostic procedures warrant identification of new methodologies to improve diagnoses of cancer patients. In this context, long non-coding RNAs (lncRNAs) have emerged as stable biomarkers which are ...