Browsing Zoology-Research Publications by Title
Now showing items 155-173 of 173
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Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
(Impact Journals LLC, 2016)Ionizing radiation (IR) induces highly cytotoxic double-strand breaks (DSBs) and also clustered oxidized bases in mammalian genomes. Base excision repair (BER) of bi-stranded oxidized bases could generate additional DSBs ... -
A short review on the implications of base excision repair pathway for neurons: Relevance to neurodegenerative diseases
(Elsevier, 2014)Oxidative DNA damage results from the attack by reactive oxygen and nitrogen species (ROS/RNS) on human genome. This includes base modifications such as oxidized bases, abasic (AP) sites, and single-strand breaks (SSBs), ... -
A short review: Doxorubicin and its effect on cardiac proteins
(Wiley-Liss Inc., 2020-12-26)Doxorubicin (DOX) is a boon for cancer-suffering patients. However, the undesirable effect�on health on vital organs, especially the heart, is a�limiting factor, resulting in an increased number of patients with cardiac ... -
Significant structural change in human c-Myc promoter G-quadruplex upon peptide binding in potassium
(Royal Society of Chemistry, 2022-03-08)We selected the G-quadruplex motif located in the nuclease-hypersensitive elements (NHE) III1 region of the c-Myc promoter and for the first time performed its interaction studies with a designed peptide (QW10). Our CD ... -
SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer
(Frontiers Media S.A., 2019)Limitations in current diagnostic procedures warrant identification of new methodologies to improve diagnoses of cancer patients. In this context, long non-coding RNAs (lncRNAs) have emerged as stable biomarkers which are ... -
Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy.
(Elsevier, 2019)The five-year survival rate of esophageal cancer patients is less than 20%. This may be due to increased resistance (acquired or intrinsic) of tumor cells to chemo/radiotherapies, often caused by aberrant cell cycle, ... -
Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
(Nature Publishing Group, 2017)The guidance protein Semaphorin7A (Sema7A) is required for the proper development of the immune and nervous systems. Despite strong expression in the mature brain, the role of Sema7A in the adult remains poorly defined. ... -
Surface modification of kevlar fabric with a novel sulfonyl aryl containing monomer and its influence on inter yarn friction
(SAGE Publications Ltd, 2023-05-04)The ballistic impact response of Kevlar textiles is significantly influenced by the friction between the yarns. It increases the dissipation of energy when yarns begin to displace relative to one another and it also results ... -
Synthesis, biological evaluation and molecular modeling studies of phenyl-/benzhydrylpiperazine derivatives as potential MAO inhibitors.
(Elsevier, 2018)Monoamine oxidase inhibitors (MAOIs) are potential drug candidates for the treatment of various neurological disorders like Parkinson's disease, Alzheimer's disease and depression. In the present study, two series of ... -
Synthesis, biological evaluation and molecular modeling studies of phenyl-/benzhydrylpiperazine derivatives as potential MAO inhibitors
(Academic Press Inc., 2018)Monoamine oxidase inhibitors (MAOIs) are potential drug candidates for the treatment of various neurological disorders like Parkinson's disease, Alzheimer's disease and depression. In the present study, two series of ... -
A Systematic Role of Metabolomics, Metabolic Pathways, and Chemical Metabolism in Lung Cancer
(MDPI, 2023-02-08)Lung cancer (LC) is considered as one of the leading causes of cancer-associated mortalities. Cancer cells� reprogrammed metabolism results in changes in metabolite concentrations, which can be utilized to identify a ... -
Type 2 Diabetes (T2DM) and Parkinson�s Disease (PD): a Mechanistic Approach
(Springer, 2023-04-28)Growing evidence suggest that there is a connection between Parkinson�s disease (PD) and insulin dysregulation in the brain, whilst the connection between PD and type 2 diabetes mellitus (T2DM) is still up for debate. ... -
Understanding human thiol dioxygenase enzymes: structure to function and biology to pathology
(Wiley, 2017)Amino acid metabolism is a significant metabolic activity in humans, especially of sulphur-containing amino acids, methionine and cysteine (Cys). Cys is cytotoxic and neurotoxic in nature; hence, mammalian cells maintain ... -
Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis
(MDPI, 2023-03-28)Genetic variant(s) of concern (VoC) of SARS-CoV-2 have been emerging worldwide due to mutations in the gene encoding spike glycoprotein. We performed comprehensive analyses of spike protein mutations in the significant ... -
Understanding the impact of sociosexual interactions on sleep using Drosophila melanogaster as a model organism
(Frontiers Media SA, 2023-08-21)Sleep is conserved across species, and it is believed that a fixed amount of sleep is needed for normal neurobiological functions. Sleep rebound follows sleep deprivation; however, continuous sleep deprivation for longer ... -
Understanding the multifaceted role of ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) and its altered behaviour in human diseases
(Bentham Science Publishers B.V., 2015)Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) also known as Autotaxin, is a secreted lysophospholipase D, which hydrolyzes lysophosphatidylcholine (LPC) into Lysophosphatidic acid (LPA). LPA is the bioactive ... -
Untangle the mystery behind DS-associated AD � Is APP the main protagonist?
(Elsevier Ireland Ltd, 2023-04-07)Amyloid precursor protein profusion in Trisomy 21, also called Down Syndrome (DS), is rooted in the genetic determination of Alzheimer's disease (AD). With the recent development in patient care, the life expectancy of DS ... -
Unveiling the mechanism of platelet dysfunction in Parkinson's disease: The effect of 6-hydroxydopamine on human blood platelets
(Elsevier Ltd, 2023-05-22)Introduction: Parkinson's disease (PD) is a progressive neuronal illness often linked to increased cardiovascular complications, such as myocardial infarction, cardiomyopathy, congestive heart failure, and coronary heart ... -
Yin and yang of immunological memory in controlling infections: Overriding self defence mechanisms
(Taylor and Francis Ltd., 2021-04-19)Immunological memory is critical for host immunity and decisive for individual to respond exponentially to previously encountered infection. Both T and B cell memory are known to orchestrate immunological memory with their ...