Browsing Zoology-Research Publications by Issue Date
Now showing items 41-60 of 173
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Modulation of midgut peritrophins' expression during plasmodium infection in anopheles stephensi (Diptera: Culicidae)
(Indian Academy of Sciences, 2017)The peritrophic matrix (PM) serves as a barrier to pathogens in many disease vectors including mosquitoes. The Plasmodium ookinete has to cross the PM barrier for its successful establishment in the mosquito midgut and ... -
Synthesis, biological evaluation and molecular modeling studies of phenyl-/benzhydrylpiperazine derivatives as potential MAO inhibitors
(Academic Press Inc., 2018)Monoamine oxidase inhibitors (MAOIs) are potential drug candidates for the treatment of various neurological disorders like Parkinson's disease, Alzheimer's disease and depression. In the present study, two series of ... -
APE1 modulates cellular responses to organophosphate pesticide-induced oxidative damage in non-small cell lung carcinoma A549 cells
(Springer New York LLC, 2018)Monocrotophos (MCP) and chlorpyrifos (CP) are widely used organophosphate pesticides (OPPs), speculated to be linked with human pathologies including cancer. Owing to the fact that lung cells are most vulnerable to the ... -
Anticancer activity of dihydropyrazolo[1,5-c]quinazolines against rat C6 glioma cells via inhibition of topoisomerase II
(Wiley-VCH Verlag, 2018)The design and synthesis of dihydropyrazolo[1,5-c]quinazolines (1a?h) as human topoisomerase II (TopoII) catalytic inhibitors are reported. The compounds were investigated for their antiproliferative activity against the ... -
Pseudomonas aeruginosa quorum sensing molecule N-3-oxo-dodecanoyl-L-homoserine lactone activates human platelets through intracellular calcium-mediated ROS generation
(Elsevier GmbH, 2018)Pseudomonas aeruginosa, an opportunistic pathogen release N-3-oxo-dodecanoyl-L-homoserine lactone (3-oxo-C12HSL) and N-butyryl-L-homoserine lactone (C4-HSL) quorum sensing (QS) molecules to regulate various virulence factors ... -
Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes.
(Springer, 2018)Maintaining genomic integrity is essential for cell survival and viability. Reactive oxygen species (ROS) overproduction results in oxidative stress leading to the genomic instability via generation of small base lesions ... -
Hormones of hypothalamus and ageing
(Springer, 2018)Hypothalamus being the master regulator of the vertebrate endocrine system undergoes many adjustments/alterations which body makes during the course of aging. Moreover, the endocrinological basis of aging in male and female ... -
Anticancer activity of dihydropyrazolo[1,5-c]quinazolines against rat C6 glioma cells via inhibition of topoisomerase II.
(Wiley, 2018)The design and synthesis of dihydropyrazolo[1,5‐c]quinazolines (1a–h) as human topoisomerase II (TopoII) catalytic inhibitors are reported. The compounds were investigated for their antiproliferative activity against the ... -
Pseudomonas aeruginosa quorum sensing molecule N-3-oxo-dodecanoyl-Lhomoserine lactone activates human platelets through intracellular calciummediated ROS generation
(Elsevier, 2018)Pseudomonas aeruginosa, an opportunistic pathogen release N-3-oxo-dodecanoyl-l-homoserine lactone (3-oxo-C12HSL) and N-butyryl-l-homoserine lactone (C4-HSL) quorum sensing (QS) molecules to regulate various virulence factors ... -
Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management
(CRC Press Taylor and Francis group, 2018)Nanoparticles have an interesting surface chemistry and are used in a wide variety of applications ranging from consumer products like socks, medical dressings, and computer chips. They have also been shown antimicrobial, ... -
Nanomaterial-Blood interactions: Biomedical perspective
(The Royal Society of Chemistry, 2018) -
A BIOCHEMICAL STUDY TO EVALUATE THE ROLE OF APURINIC/APYRIMIDINIC ENDONUCLEASE 1 (APE1) IN LUNG CANCER PROGRESSION
(Central University of Punjab, 2018)Globally, lung cancer has the highest incidence and mortality rate. Environmental factors such as chlorpyrifos (CP) and monocrotophos (MCP), widely used organophosphate pesticides (OPPs), and are reported to be involved ... -
ORGANOPHOSPHATE PESTICIDES PESTER Aβ- INDUCED GENOTOXIC RESPONSES IN CULTURED NEURONAL CELLS: APE1/Ref-1 MEDIATED INTERVENTION
(Central University of Punjab, 2018)Amyloid beta ( ) peptide deposition is the primary cause of neurodegeneration in reasons deposition, but the actual cause is not apparent. Several reports point towards the role of pesticides in the AD pathogenesis, ... -
Identification of novel indole based heterocycles as selective estrogen receptor modulator.
(Elsevier, 2018)In the present study, we have designed and synthesized indole derivatives by coalescing the indole nucleus with chromene carbonitrile and dihydropyridine nucleus. Two compounds 5c and 6d were selected from series I and II ... -
Anticancer activity of dihydropyrazolo [1, 5‐c] quinazolines against rat C6 glioma cells via inhibition of topoisomerase II
(wiley, 2018)The design and synthesis of dihydropyrazolo[1,5‐c]quinazolines (1a–h) as human topoisomerase II (TopoII) catalytic inhibitors are reported. The compounds were investigated for their antiproliferative activity against the ... -
Design, synthesis and biological evaluation of novel indole-benzimidazole hybrids targeting estrogen receptor alpha (ER-?)
(Elsevier Masson SAS, 2018)In the course of efforts to develop novel selective estrogen receptor modulators (SERMs), indole-benzimidazole hybrids were designed and synthesised by fusing the indole nucleus with benzimidazole. All the compounds were ... -
Atypical leishmaniasis: A global perspective with emphasis on the Indian subcontinent
(Public Library of Science, 2018)Background: Among the neglected tropical diseases, leishmaniasis continues to be prevalent in many tropical and subtropical countries despite international, national, and local efforts towards its control and elimination ... -
Synthesis, biological evaluation and molecular modeling studies of phenyl-/benzhydrylpiperazine derivatives as potential MAO inhibitors.
(Elsevier, 2018)Monoamine oxidase inhibitors (MAOIs) are potential drug candidates for the treatment of various neurological disorders like Parkinson's disease, Alzheimer's disease and depression. In the present study, two series of ... -
Low dose radiation primed iNOS + M1macrophages modulate angiogenic programming of tumor derived endothelium.
(PLOS, 2018)Solid tumors are covered by stroma, which is hypoxic in nature and composed of various non‐malignant components such as endothelial cells, fibroblasts, and pericytes that support tumor growth. Tumor stroma represents a ... -
Midgut de novo transcriptome analysis and gene expression profiling of Achaea janata larvae exposed with Bacillus thuringiensis (Bt)-based biopesticide formulation
(Elsevier, 2019)India is the major producer and exporter of castor oil in the world. Castor semilooper, Achaea janata is one of the main castor crop pests, which causes serious economic loss of crop, hence management and control of the ...