Browsing Animal Sciences-Research Publications by Author "Arwai, Andrew S."

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Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes

Tsutakawa, Susan E.; Shin, David S.; Mol, Clifford D.; Lzumi, Tadahide; Arwai, Andrew S.; Mantha, Anil K.; Szczesny, Bartosz; Ivanov, Ivaylo N.; Hosfield, David J.; Maiti, Buddhadev; Pique, Mike E.; Frankel, Kenneth A.; Hitomi. Kenichi; Cunnigham, Richard, P.; Mitra, Sankar; Tainer, John A. (2013)

Non-coding apurinic/apyrimidinic (AP) sites in DNA form spontaneously and as DNA base excision repair intermediates are the most common toxic and mutagenic in vivo DNA lesion. For repair,APsites must be processed by 5' AP ...