Browsing Zoology-Research Publications by Author "Parkash, Jyoti"

Now showing items 1-10 of 10

    • 4,6-Diphenylpyrimidine Derivatives as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase for the Treatment of Alzheimer's Disease 

      Kumar, B; Dwivedi, A.R; Sarkar, B; Gupta, S.K; Krishnamurthy, S; Mantha, Anil K; Parkash, Jyoti; Kumar, Vinod (American Chemical Society, 2019)
      Alzheimer's disease (AD) is a neurodegenerative disorder with multifactorial pathogenesis. Monoamine oxidase (MAO) and acetylcholinesterase enzymes (AChE) are potential targets for the treatment of AD. A total of 15 new ...

    • Association of IRGM gene promoter polymorphisms with hepatitis B virus infection 

      Sharma, Ambika; Duseja, Ajay; Parkash, Jyoti; Changotra, Harish (John Wiley and Sons Inc, 2022-06-04)
      Background: In response to intracellular pathogens, the autophagy gene IRGM plays an essential role in the innate immune response. Various identified IRGM gene risk loci are associated with several diseases but, so far, ...

    • ATG5: A central autophagy regulator implicated in various human diseases 

      Changotra, Harish; Kaur, Sargeet; Yadav, Suresh Singh; Gupta, Girdhari Lal; Parkash, Jyoti; Duseja, Ajay (John Wiley and Sons Ltd, 2022-09-05)
      Autophagy, an intracellular conserved degradative process, plays a central role in the renewal/recycling of a cell to maintain the homeostasis of nutrients and energy within the cell. ATG5, a key component of autophagy, ...

    • Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase 

      Kumar, Bhupinder; Kumar, V; Prashar, V; Saini, S; Dwivedi, A.R; Bajaj, B; Mehta, D; Parkash, Jyoti; Kumar, Vinod (Elsevier, 2019)
      Alzheimer's disease (AD) is a multifactorial neurological disorder involving complex pathogenesis. Single target directed drugs proved ineffective and since last few years' different pharmacological strategies including ...

    • Gametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus: Putative underlying mechanistic cascade 

      Singh, Ankur; Lal, Bechan; Parkash, Jyoti; Millar, Robert P. (Elsevier Inc., 2021-06-28)
      Unlike mammals, two kisspeptins genes encoding, kiss1 and kiss2 are detected in fishes with highly varied and contradictory difference in their reproductive activities. The present study was undertaken to examine the direct ...

    • Hormones of hypothalamus and ageing 

      Kaur, Gurcharan; Parkash, Jyoti (Springer, 2018)
      Hypothalamus being the master regulator of the vertebrate endocrine system undergoes many adjustments/alterations which body makes during the course of aging. Moreover, the endocrinological basis of aging in male and female ...

    • Investigating regulatory signatures of human autophagy related gene 5 (ATG5) through functional in silico analysis 

      Vij, Avni; Randhawa, Rohit; Parkash, Jyoti; Changotra, Harish; Vij, A.; Randhawa, R.; Parkash, J.; Changotra, H. (Elsevier B.V., 2016)
      Autophagy is an essential, homeostatic process which removes damaged cellular proteins and organelles for cellular renewal. ATG5, a part of E3 ubiquitin ligase-like complex (Atg12-Atg5/Atg16L1), is a key regulator involved ...

    • A microRNA switch regulates the rise in hypothalamic GnRH production before puberty 

      Messina, Andrea; Langlet, Fanny; Chachlaki, Konstantina; Roa, Juan; Rasika, Sowmyalakshmi; Jouy, Nathalie; Gallet, Sarah; Gaytan, Francisco; Parkash, Jyoti; Tena-Sempere, Manuel; Giacobini, Paolo; Prevot, Vincent; Messina, A.; Langlet, F.; Chachlaki, K.; Roa, J.; Rasika, S.; Jouy, N.; Gallet, S.; Gaytan, F.; Parkash, J.; Tena-Sempere, M.; Giacobini, P.; Prevot, V. (Nature Publishing Group, 2016)
      A sparse population of a few hundred primarily hypothalamic neurons forms the hub of a complex neuroglial network that controls reproduction in mammals by secreting the 'master molecule' gonadotropin-releasing hormone ...

    • Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management 

      Parkash, Jyoti; Sharma, Arti; Jairath, Ankur (CRC Press Taylor and Francis group, 2018)
      Nanoparticles have an interesting surface chemistry and are used in a wide variety of applications ranging from consumer products like socks, medical dressings, and computer chips. They have also been shown antimicrobial, ...

    • Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors 

      Jongbloets, Bart C.; Lemstra, Suzanne; Schellino, Roberta; Broekhoven, Mark H.; Parkash, Jyoti; Hellemons, Anita J.C.G.M.; Mao, Tianyi; Giocobini, Paolo; Praag, Henriette Van; Marchis, Silvia De; Ramakers, Geert M.J.; Pasterkamp, R. Jeroen; Jongbloets, B.C.; Lemstra, S.; Schellino, R.; Broekhoven, M.H.; Parkash, J.; Hellemons, A.J.C.G.M.; Mao, T.; Giacobini, P.; Van Praag, H.; De Marchis, S.; Ramakers, G.M.J.; Pasterkamp, R.J. (Nature Publishing Group, 2017)
      The guidance protein Semaphorin7A (Sema7A) is required for the proper development of the immune and nervous systems. Despite strong expression in the mature brain, the role of Sema7A in the adult remains poorly defined. ...