Browsing Zoology-Research Publications by Subject "Genotoxicity"
Now showing items 1-2 of 2
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Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair
(Impact Journals LLC, 2016)Apurinic/apyrimidinic (AP) sites are frequently generated in the genome by spontaneous depurination/depyrimidination or after removal of oxidized/modified bases by DNA glycosylases during the base excision repair (BER) ... -
Human apurinic/apyrimidinic endonuclease (APE1) is acetylated at DNA damage sites in chromatin, and acetylation modulates its DNA repair activity
(American Society for Microbiology, 2016)Apurinic/apyrimidinic (AP) sites, the most frequently formed DNA lesions in the genome, inhibit transcription and block replication. The primary enzyme that repairs AP sites in mammalian cells is the AP endonuclease (APE1), ...